UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

 

SCHEDULE 14A

PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE

SECURITIES EXCHANGE ACT OF 1934

Filed by the Registrant  ☒                            Filed by a Party other than the Registrant  

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Preliminary Proxy Statement

Confidential, for Use of the Commission Only (as permitted byRule 14a-6(e)(2))

Definitive Proxy Statement

Definitive Additional Materials

Soliciting Material Pursuant to§240.14a-11(c) §240.14a-11(c) or§240.14a-2 §240.14a-2

Otonomy, Inc.

(Name of Registrant as Specified In Its Charter)

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OTONOMY, INC.

Dear Stockholder:

I am pleased to invite you to attend the 20202021 Annual Meeting of Stockholders (the “Annual Meeting”) of Otonomy, Inc. (“Otonomy”), which will be held at our principal executive offices, located at 4796 Executive Drive, San Diego, California 92121 on June 23, 202022, 2021 at 8:00 a.m. Pacific Time. Doors open at 7:30 a.m. Pacific Time. As noted in the Notice ofThe Annual Meeting of Stockholders, while we hope that we can holdwill be conducted virtually via live webcast. You will be able to attend the Annual Meeting in person, we are sensitiveby visiting www.virtualshareholdermeeting.com/OTIC2021, where you will be able to listen to the health, safetymeeting live, submit questions and travel concerns of our stockholders and federal, state and local government recommendations and restrictions imposed in response tovote online by entering the novel coronavirus(COVID-19) pandemic, and we are prepared to do so online if it is prudent basedcontrol number located on conditions at that time.your proxy card.

The attached Notice of Annual Meeting of Stockholders and proxy statement contain details of the business to be conducted at the Annual Meeting.

Whether or not you attend the Annual Meeting, it is important that your shares be represented and voted at the meeting. Therefore, I urge you to promptly vote and submit your proxy via the Internet, by phone, or by signing, dating and returning the enclosed proxy card in the enclosed envelope. If you decide to attend the Annual Meeting, you will be able to change your vote in person,or revoke your proxy, even if you have previously submitted your proxy.

On behalf of Otonomy, I would like to thank you for your continued support.

Sincerely,

David A. Weber, Ph.D.

President and Chief Executive Officer

 

 


 

LOGO

David A. Weber, Ph.D.

President and Chief Executive Officer


OTONOMY, INC.

4796 Executive Drive

San Diego, California 92121

NOTICE OF ANNUAL MEETING OF STOCKHOLDERS

 

Time and Date

June 23, 202022, 2021 at 8:00 a.m. Pacific Time

Place*

Otonomy, Inc., located at 4796 Executive Drive, San Diego, California 92121.

Place

The Annual Meeting will be a completely virtual meeting of stockholders, to be conducted via live webcast. You will be able to attend the Annual Meeting virtually, submit questions and vote online during the meeting by visiting www.virtualshareholdermeeting.com/OTIC2021.

Items of Business

•        To elect threetwo directors from the nominees described in this proxy statement.

•        To approve, on anon-binding advisory basis, the compensation paid to our named executive officers as disclosed in this proxy statement.

•  To approve, on anon-binding advisory basis, the frequency of futurenon-binding stockholder advisory votes to approve the compensation paid to our named executive officers.

•        To ratify the selection of Ernst & Young LLP as our independent registered public accounting firm for fiscal year 2020.

2021.

•        To transact other business that may properly come before the Annual Meeting or any adjournments or postponements thereof.

Record Date

April 24, 202023, 2021 (the “Record Date”). Only stockholders of record at the close of business on the Record Date are entitled to receive notice of, and to vote at, the Annual Meeting.

Proxy Voting

IMPORTANT

Please vote your shares at your earliest convenience. This will ensure the presence of a quorum at the meeting. Promptly voting your shares via the Internet, by telephone, or by signing, dating, and returning the enclosed proxy card will save the expenses and extra work of additional solicitation. If you wish to vote by mail, we have enclosed an addressed envelope, postage prepaid if mailed in the United States. Submitting your proxy now will not prevent you from voting your shares at the meeting, as your proxy is revocable at your option.

Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting to Be Held on June 23, 2020. 22, 2021. Our proxy statement and Annual Report to Stockholders are available on our website at http://investors.otonomy.com in the Financial Information section of our Investor Relations webpage.

* We currently intend to hold our Annual Meeting in person. However, we are actively monitoring the coronavirus(COVID-19) pandemic and we are sensitive to the health, safety and travel concerns of our stockholders and federal, state and local government recommendations and restrictions imposed in response to the pandemic. Accordingly, in the event it is not possible or advisable to hold our Annual Meeting at a physical location, we will announce alternative arrangements, including holding our Annual Meeting virtually at www.virtualshareholdermeeting.com/OTIC2020, as soon as practicable, by press release, which will be posted to our website at http://investors.otonomy.com/news-releases. If you are planning to attend our Annual Meeting in person, please be sure to check our website for any updates in the days before the date of our Annual Meeting. If our Annual Meeting is held virtually, you will need the control number included on your Notice or proxy card in order to be admitted to the meeting, and you will be able to submit your questions and vote your shares electronically during the meeting by following the instructions available on the meeting website.

 

By order of the Board of Directors,

LOGO

Paul E. Cayer

Chief Financial and Business Officer

San Diego, California

April 27, 202028, 2021

The date of this proxy statement is April 27, 202028, 2021 and it is being mailed to stockholders on or about May 6, 2020.

2021.


TABLE OF CONTENTS

 

Page

QUESTIONS AND ANSWERS ABOUT THEANNUALMEETING

1

BOARD OF DIRECTORS ANDCORPORATEGOVERNANCE

9

7

Nomineesfor Director

9

7

Continuing Directors

10

8

DirectorIndependence

12

9

Board LeadershipStructure

13

10

Board Meetingsand Committees

13

10

Audit Committee

13

10

CompensationCommittee

14

11

Corporate Governance andNominatingCommittee

15

11

Compensation Committee Interlocks andInsiderParticipation

15

12

Considerations in EvaluatingDirectorNominees

15

12

Stockholder Recommendations for Nominations to the Boardof Directors

16

13

Communications with the Boardof Directors

17

13

Corporate Governance Guidelines and Code of Business Conductand Ethics

17

13

Role of the Board in Risk Oversight

14

18

DirectorCompensation

14

Director Compensation

18

PROPOSAL NO. 1 ELECTIONOFDIRECTORS

20

16

Nominees

20

16

Vote Required

20

16

PROPOSAL NO. 2 ADVISORY VOTE ON THE COMPENSATION OF OUR NAMED EXECUTIVE OFFICERS

21

17

Vote Required

21

17

PROPOSAL NO. 3 ADVISORY VOTE ON THE FREQUENCY OF FUTURE NON-BINDING STOCKHOLDER ADVISORY VOTES TO APPROVE THE COMPENSATION PAID TO OUR NAMED EXECUTIVE OFFICERS

22

Vote Required

22

PROPOSAL NO. 4 RATIFICATION OF APPOINTMENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

23

18

Fees Paid to the Independent Registered PublicAccounting Firm

23

18

Auditor Independence

23

18

Audit Committee Policy onPre-Approval of Audit and PermissibleNon-Audit Services of Independent Registered PublicAccounting Firm

24

18

Vote Required

24

18

AUDITCOMMITTEEREPORT

25

19

EXECUTIVEOFFICERS

27

20

EXECUTIVECOMPENSATION

28

21

Processes and Procedures for Compensation DecisionsOverview

28

21

SummaryCompensationTable

29

22

Outstanding Equity Awards at FiscalYear-End 2019 2020

23

30

ExecutiveEmploymentAgreements

24

Equity CompensationPlan Information

26

Executive Employment Agreements

31

Equity Compensation Plan Information

34

SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERSANDMANAGEMENT

35

27

RELATEDPERSONTRANSACTIONS

37

29

OTHERMATTERS

39

30

Delinquent Section 16(a) ReportsBeneficial OwnershipReportingCompliance

39

30

Fiscal Year 20192020 Annual Report and SEC Filings

39

30

Company Website

39

30

PROPOSALS OF STOCKHOLDERS FOR 20212022 ANNUAL MEETING

40

31

 

i


OTONOMY, INC.

PROXY STATEMENT

FOR 20202021 ANNUAL MEETING OF STOCKHOLDERS

To Be Held at 8:00 a.m. Pacific Time on June 23, 202022, 2021

This proxy statement and the enclosed form of proxy are furnished in connection with the solicitation of proxies by our board of directors for use at our 20202021 Annual Meeting of Stockholders (the “Annual Meeting”), and any postponements, adjournments or continuations thereof. The Annual Meeting will be held on June 23, 202022, 2021 at 8:00 a.m. Pacific Time at our principal executive offices, located at 4796 Executive Drive, San Diego, California 92121.virtually via live webcast. You will be able to attend the Annual Meeting virtually by visiting www.virtualshareholdermeeting.com/OTIC2021, where you will be able to listen to the meeting live, submit questions and vote online by entering the control number on your proxy card.

QUESTIONS AND ANSWERS ABOUT THE ANNUAL MEETING

The information provided in the “question and answer” format below addresses certain frequently asked questions but is not intended to be a summary of all matters contained in this proxy statement. Please read the entire proxy statement carefully before voting your shares.

Why am I receiving these materials?

The board of directors is providing these proxy materials to you in connection with its solicitation of proxies for use at Otonomy’s Annual Meeting, which will take place on June 23, 2020.22, 2021. Stockholders are invited to virtually attend the Annual Meeting and are requested to vote on the proposals described in this proxy statement. This proxy statement and the accompanying proxy card are being mailed on or about May 6, 20202021 in connection with the solicitation of proxies on behalf of the board of directors.

What proposals will be voted on at the Annual Meeting?

There are fourthree proposals scheduled to be voted on at the Annual Meeting:

the election of threetwo Class IIII directors to hold office until the 20232024 annual meeting of stockholders or until their successors are duly elected and qualified;

the approval, on anon-binding advisory basis, of the compensation paid to our named executive officers as disclosed in this proxy statement; and

the approval, on anon-binding advisory basis, of the frequency of futurenon-binding stockholder advisory votes to approve the compensation paid to our named executive officers; and

the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2020.2021.

At the time this proxy statement was mailed, our management and board of directors were not aware of any other matters to be presented at the Annual Meeting other than those set forth in this proxy statement and in the notice accompanying this proxy statement.

How does our board of directors recommend that I vote?

The board of directors recommends that you vote:

FOR the election of each of the threetwo directors nominated by the board of directors and named in this proxy statement as Class IIII directors to serve for a three-year term;

FOR the approval, on anon-binding advisory basis, of the compensation paid to our named executive officers as disclosed in this proxy statement; and

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To hold futurenon-binding stockholder advisory votes to approve the compensation paid to our named executive officers every “ONE YEAR”; and

FOR the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2020.2021.

Who is entitled to vote at the Annual Meeting?

Holders of our common stock at the close of business on April 24, 2020,23, 2021, the record date for the Annual Meeting (the “Record Date”), are entitled to notice of and to vote at the Annual Meeting. Each stockholder is entitled to one vote for each share of our common stock held as of the Record Date. As of the Record Date, there were 30,814,21156,618,092 shares of common stock outstanding and entitled to vote. Stockholders are not permitted to cumulate votes with respect to the election of directors. The shares you are entitled to vote include shares that are (1) held of record directly in your name, and (2) held for you as the beneficial owner through a stockbroker, bank or other nominee.


What is the difference between holding shares as a stockholder of record and as a beneficial owner?

Stockholder of Record: Shares Registered in Your Name. If, at the close of business on the Record Date, your shares were registered directly in your name with EQ Shareowner Services, our transfer agent, then you are considered the stockholder of record with respect to those shares. As the stockholder of record, you have the right to grant your voting proxy directly to the individuals listed on the proxy card or to vote in person atduring the virtual Annual Meeting.

Beneficial Owners: Shares Registered in the Name of a Broker, Bank or Other Nominee. If, at the close of business on the Record Date, your shares were held, not in your name, but rather in a stock brokerage account or by a bank or other nominee on your behalf, then you are considered the beneficial owner of shares held in “street name.” As the beneficial owner, you have the right to direct your broker, bank or other nominee how to vote your shares by following the voting instructions your broker, bank or other nominee provides. If you do not provide your broker, bank or other nominee with instructions on how to vote your shares, your broker, bank or other nominee may, in its discretion, vote your shares with respect to routine matters but may not vote your shares with respect to anynon-routine matters. Please see “What if I do not specify how my shares are to be voted?” for additional information.

DoWhat do I haveneed to do anything in advance if I plan to virtually attend the Annual Meeting in person?Meeting?

Stockholder of Record: Shares Registered in Your Name. If you were a stockholder of record at the close of business on the Record Date, you do not need to do anything in advance to virtually attend and/or vote your shares in person at the Annual Meeting, but you will need to present government-issued photo identification for entrance to the Annual Meeting.

Beneficial Owners: Shares Registered in the Name of a Broker, Bank or Other Nominee. If you were a beneficial owner at the close of business on the Record Date, you may not vote your shares in person at the Annual Meeting unless you obtain a “legal proxy” from your broker, bank or other nominee who is the stockholder of record with respect to your shares. You may still virtually attend the Annual Meeting even if you do not have a legal proxy. For entrance

You will be able to attend the Annual Meeting virtually, submit your questions during the meeting and vote your shares electronically at the meeting by visiting www.virtualshareholdermeeting.com/OTIC2021. To participate in the Annual Meeting, you will need to provide proof of beneficial ownership as of the Record Date, such as the notice or voting instructions you received from your broker, bank or other nominee or a brokerage statement reflecting your ownership of shares as of the Record Date, and also present government-issued photo identification.

Please note that no cameras, recording equipment, bags, briefcases or packages will be permitted in the Annual Meeting.

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We currently intend to hold our Annual Meeting in person. However, we are actively monitoring the coronavirus(COVID-19) pandemic and we are sensitive to the health, safety and travel concerns of our stockholders and federal, state and local government recommendations and restrictions imposed in response to the pandemic. Accordingly, in the event it is not possible or advisable to hold our Annual Meeting at a physical location, we will announce alternative arrangements, including holding our Annual Meeting virtually at www.virtualshareholdermeeting.com/OTIC2020, as soon as practicable, by press release, which will be posted to our website at http://investors.otonomy.com/news-releases. If our Annual Meeting is held virtually, you will need the control number included onfrom your Notice ofproxy card. The Annual Meeting of Stockholders or proxy card in orderwebcast will begin promptly at 8:00 a.m. Pacific Time. We encourage you to be admittedaccess the meeting prior to the meeting,start time. Online check-in will begin at 7:45 a.m. Pacific Time, and you will be able to submit your questions and vote your shares electronically duringshould allow ample time for the meeting by following the instructions available on the meeting website.check-in procedures.

How do I vote and what are the voting deadlines?

Stockholder of Record: Shares Registered in Your Name. If you are a stockholder of record, you can vote in one of the following ways:

You may vote via the Internet. To vote via the Internet, go to http://www.proxyvote.com to complete an electronic proxy card. You will be asked to provide the control number from the proxy card you receive. Your vote must be received by 11:59 p.m. Eastern Time on June 22, 202021, 2021 to be counted. If you vote via the Internet, you do not need to return a proxy card bymail.

You may vote by telephone.To vote by telephone, dial toll-free1-800-690-6903 and follow the recorded instructions. You will be asked to provide the control number from the proxy card. Your vote must be received by 11:59 p.m. Eastern Time on June 22, 202021, 2021 to be counted. If you vote by telephone, you do not need to return a proxy card bymail.

You may vote by mail. If you would like to vote by mail, you need to complete, date and sign the proxy card that accompanies this proxy statement and promptly mail it to the tabulation agent in the enclosed postage-paid envelope so that it is received no later than June 22, 2020.21, 2021. You do not need to put a stamp on the enclosed envelope if you mail it from within the United States. The persons named in the proxy card will vote the shares you own in accordance with your instructions on the proxy card you mail. If you return the proxy card, but do not give any instructions on a particular matter to be voted on at the Annual Meeting, the persons named in the proxy card will vote the shares you own in accordance with the recommendations of the Board. The board of directors recommends that you voteFORthe election of each of the threetwo directors nominated by our board of directors and named in this proxy statement as Class IIII directors to serve for a three-year term;FOR the approval, on anon-binding advisory basis, of the compensation paid to our named executive officers, as disclosed in this proxy statement; and to hold futurenon-bindingFOR stockholder advisory votes to approve the compensation paid to our named executive officers every “ONE YEAR”; andFORthe ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2020.2021.

You may vote in personvirtually during the Annual Meeting. If you plan to attend the Annual Meeting by visiting www.virtualshareholdermeeting.com/OTIC2021, you may vote by deliveringyou may vote electronically during the meeting. Please have your completed proxy card in person or by completing and submitting a ballot, which will be provided athand when you visit the Annual Meeting.website.


Beneficial Owners: Shares Registered in the Name of a Broker, Bank or Other Nominee. If you are the beneficial owner of shares held of record by a broker, bank or other nominee, you will receive voting instructions fromyourbroker,bankorothernominee.Youmustfollowthevotinginstructionsprovidedbyyourbroker,bankor other nominee. You must follow the voting instructions provided by nomineeinordertoinstructyourbroker,bankorothernominee in order howto instruct voteyour broker, bank or other nominee how to vote your shares.Theavailabilityof Internetandtelephonevotingoptionswilldependonthevotingprocessofyourbroker,bankorothernominee.As discussedabove,ifyouareabeneficialowner,youmaynotvoteyourshares in person attheAnnualMeeting unlessyouobtainalegalproxyfromyourbroker,bankorothernominee.

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Can I change my vote or revoke my proxy?

Stockholder of Record: Shares Registered in Your Name. If you are a stockholder of record, you may revoke your proxy or change your proxy instructions at any time before your proxy is voted at the Annual Meeting by:

entering a new vote by Internet ortelephone;

signing and returning a new proxy card with a laterdate;

delivering a written revocation to our Secretary at Otonomy, Inc., 4796 Executive Drive, San Diego, California 92121, by 11:59 p.m. Eastern Time on June 22, 2020; 21, 2021;or

attending the Annual Meeting and voting in person.during the virtual meeting.

Beneficial Owners: Shares Registered in the Name of a Broker, Bank or Other Nominee. If you are the beneficial owner of your shares, you must contact the broker, bank or other nominee holding your shares and follow their instructions to change your vote or revoke your proxy.

What is the effect of giving a proxy?

Proxies are solicited by and on behalf of our board of directors. The persons named in the proxy have been designated as proxy holders by our board of directors. When a proxy is properly dated, executed and returned, the shares represented by the proxy will be voted at the Annual Meeting in accordance with the instructions of the stockholder. If no specific instructions are given, however, the shares will be voted in accordance with the recommendations of our board of directors. If any matters not described in this proxy statement are properly presented at the Annual Meeting, the proxy holders will use their own judgment to determine how to vote your shares. If the Annual Meeting is postponed or adjourned, the proxy holders can vote your shares on the new meeting date, unless you have properly revoked your proxy, as described above.

What if I do not specify how my shares are to be voted?

Stockholder of Record: Shares Registered in Your Name. If you are a stockholder of record and you submit a proxy but you do not provide voting instructions, your shares will be voted:

“FOR” the election of each of the threetwo directors nominated by our board of directors and named in this proxy statement as Class IIII directors to serve for a three-year term (Proposal No.1);

“FOR” the approval, on anon-binding advisory basis, of the compensation paid to our named executive officers as disclosed in this proxy statement (Proposal No. 2); and

To hold futurenon-binding stockholder advisory votes to approve the compensation paid to our named executive officers every “ONE YEAR” (Proposal No. 3);

“FOR” the ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 20202021 (Proposal No. 4)3); and

In the discretion of the named proxy holders regarding any other matters properly presented for a vote at the Annual Meeting or any adjournments or postponements thereof.

Beneficial Owners: Shares Registered in the Name of a Broker, Bank or Other Nominee. If you are a beneficial owner and you do not provide your broker, bank or other nominee that holds your shares with voting instructions, then your broker, bank or other nominee will determine if it has discretion to vote on each matter.

Brokers do not have discretion to vote onnon-routine matters. Proposal No. 1 ,and Proposal No. 2 and Proposal No. 3 arenon-routine matters, while Proposal No. 43 is a routine matter. As a result, if you do not provide voting instructions to your broker, bank or other nominee, then your broker, bank or other nominee may not vote your shares with respect to ProposalsProposal No. 1 2 and 3,Proposal No. 2, which would result in a “brokernon-vote,” but may, in its discretion, vote your shares with respect to Proposal No. 4.3. For additional information regarding brokernon-votes, see “What are the effects of abstentions and brokernon-votes?” below.


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What are the effects of abstentions and brokernon-votes?

An abstention represents a stockholder’s affirmative choice to decline to vote on a proposal. If a stockholder indicates on its proxy card that it wishes to abstain from voting its shares, or if a broker, bank or other nominee holding its customers’ shares of record causes abstentions to be recorded for shares, these shares will be considered present and entitled to vote at the Annual Meeting. As a result, abstentions will be counted for purposes of determining the presence or absence of a quorum and will also count as votes against a proposal in cases where approval of the proposal requires the affirmative vote of a majority of the shares present and entitled to vote at the Annual Meeting (e.g., Proposals No. 2 and 4)3). However, because the outcome of Proposal No. 1 (election of directors) will be determined by a plurality vote, and Proposal No. 3 will be determined by the frequency receiving the highest number of votes cast, abstentions will have no impact on the outcome of such proposal as long as a quorum exists.

A brokernon-vote occurs when a broker, bank or other nominee holding shares for a beneficial owner does not vote on a particular proposal because the broker, bank or other nominee does not have discretionary voting power with respect to such proposal and has not received voting instructions from the beneficial owner of the shares. Brokernon-votes will be counted for purposes of calculating whether a quorum is present at the Annual Meeting but will not be counted for purposes of determining the number of votes cast. Therefore, a brokernon-vote will make a quorum more readily attainable but will not otherwise affect the outcome of the vote on any proposal.

What is a quorum?

A quorum is the minimum number of shares required to be present at the Annual Meeting for the meeting to be properly held under our bylaws and Delaware law. A majority of the shares of common stock outstanding and entitled to vote, in person (including virtually) or by proxy, constitutes a quorum for the transaction of business at the Annual Meeting. As noted above, as of the Record Date, there were a total of 30,814,21156,618,092 shares of common stock outstanding, which means that 15,407,10628,309,047 shares of common stock must be represented in person (including virtually) or by proxy at the Annual Meeting to have a quorum. If there is no quorum, a majority of the shares present at the Annual Meeting may adjourn the meeting to a later date.

How many votes are needed for approval of each proposal?

Proposal No. 1:The election of Class III directors requires a plurality vote of the shares of our common stock present in person or by proxy at the Annual Meeting and entitled to vote thereon to be approved. This means that the three nominees who receive the most FOR votes will be elected. You may (i) vote FOR all nominees, (ii) WITHHOLD your vote as to all nominees, or (iii) vote FOR all nominees except for those specific nominees from whom you WITHHOLD your vote. Any shares not voted FOR a particular nominee (whether as a result of voting withheld or a brokerProposal No. 1: The election of Class I directors requires a plurality vote of the shares of our common stock present in person (including virtually) or by proxy at the Annual Meeting and entitled to vote thereon to be approved. This means that the two nominees who receive the most FOR votes will be elected. You may (i) vote FOR all nominees, (ii) WITHHOLD your vote as to all nominees, or (iii) vote FOR all nominees except for those specific nominees from whom you WITHHOLD your vote. Any shares not voted FOR a particular nominee (whether as a result of voting withheld or a broker non-vote) will not be counted in such nominee’s favor and will have no effect on the outcome of the election. If you WITHHOLD your vote as to all nominees, you will be deemed to have abstained from voting on Proposal No. 1, and such abstention will have no effect on the outcome of theproposal. will not be counted in such nominee’s favor and will have no effect on the outcome of the election. If you WITHHOLD your vote as to all nominees, you will be deemed to have abstained from voting on Proposal No. 1, and such abstention will have no effect on the outcome of the proposal.

Proposal No. 2:The approval, on anon-binding advisory basis, of the compensation paid to our named executive officers as disclosed in this proxy statement requires an affirmative vote of a majority of the shares of our common stock present in person or by proxy at the Annual Meeting and entitled to vote thereon to be approved. You may vote FOR, AGAINST or ABSTAIN. If you ABSTAIN from voting on Proposal No. 2, the abstention will have the same effect as a vote AGAINST the proposal. Brokernon-votes will have no effect on the outcome of Proposal No. 2. Because Proposal No. 2 is an advisory vote, the result will not be binding on our board of directors or our company. Our board of directors and our compensation committee will consider the outcome of the vote when determining named executive officer compensation.

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Proposal No. 2: The approval, on a non-binding advisory basis, of the compensation paid to our named executive officers as disclosed in this proxy statement requires an affirmative vote of a majority of the shares of our common stock present in person (including virtually) or by proxy at the Annual Meeting and entitled to vote thereon to be approved. You may vote FOR, AGAINST or ABSTAIN. If you ABSTAIN from voting on Proposal No. 2, the abstention will have the same effect as a vote AGAINST the proposal. Broker non-votes will have no effect on the outcome of Proposal No. 2. Because Proposal No. 2 is an advisory vote, the result will not be binding on our board of directors or our company. Our board of directors and our compensation committee will consider the outcome of the vote when determining named executive officer compensation.


Proposal No. 3:For the approval, on anon-bindingProposal No. 3: The ratification of the appointment of Ernst & Young LLP requires an affirmative vote of a majority of the shares of our common stock present in person (including virtually) or by proxy at the Annual Meeting and entitled to vote thereon to be approved. You may vote FOR, AGAINST or ABSTAIN. If you ABSTAIN from voting on Proposal No. 3, the abstention will have the same effect as a vote AGAINST the proposal. advisory basis, of the frequency of futurenon-binding stockholder advisory votes to approve the compensation paid to our named executive officers, the frequency(1-year,2-years or3-years) receiving the highest number of votes cast at the Annual Meeting by stockholders entitled to vote thereon will be considered the frequency preferred by the stockholders. If you ABSTAIN from voting on Proposal No. 3, it will have no effect on the outcome. Brokernon-votes also will have no effect on the outcome of Proposal No. 3. Because Proposal No. 3 is an advisory vote, the result will not be binding on our board of directors or our company. Our board of directors and our compensation committee will consider the outcome of the vote when determining how often we should submit to stockholders anon-binding stockholder advisory vote to approve the compensation paid to our named executive officers.

Proposal No. 4:The ratification of the appointment of Ernst & Young LLP requires an affirmative vote of a majority of the shares of our common stock present in person or by proxy at the Annual Meeting and entitled to vote thereon to be approved. You may vote FOR, AGAINST or ABSTAIN. If you ABSTAIN from voting on Proposal No. 4, the abstention will have the same effect as a vote AGAINST the proposal.

How are proxies solicited for the Annual Meeting and who is paying for such solicitation?

Our board of directors is soliciting proxies for use at the Annual Meeting by means of the proxy materials.

We will bear the entire cost of proxy solicitation, including the preparation, assembly, printing, mailing and distribution of the proxy materials. Copies of solicitation materials will also be made available upon request to brokers, banks and other nominees to forward to the beneficial owners of the shares held of record by such brokers, banks or other nominees. The original solicitation of proxies may be supplemented by solicitation by telephone, electronic communication, or other means by our directors, officers, employees or agents. No additional compensation will be paid to these individuals for any such services, although we may reimburse such individuals for their reasonableout-of-pocket expenses in connection with such solicitation. We do not plan to retain a proxy solicitor to assist in the solicitation of proxies.


If you choose to access the proxy materials and/or vote over the Internet, you are responsible for Internet access charges you may incur. If you choose to vote by telephone, you are responsible for telephone charges you may incur.

What does it mean if I received more than one Notice?

If you receive more than one Notice, your shares may be registered in more than one name or in different accounts. Please follow the voting instructions on each Notice to ensure that all of your shares are voted.

Is my vote confidential?

Proxy instructions, ballots and voting tabulations that identify individual stockholders are handled in a manner that protects your voting privacy. Your vote will not be disclosed either within Otonomy or to third parties, except as necessary to meet applicable legal requirements, to allow for the tabulation of votes and certification of the vote, or to facilitate a successful proxy solicitation.

I share an address with another stockholder, and we received only one paper copy of the proxy materials. How may I obtain an additional copy of the proxy materials?

We have adopted a procedure approved by the Securities and Exchange Commission (the “SEC”) called “householding,“householding,” under which we can deliver a single copy of the proxy materials and annual report to multiple stockholders who share the same address unless we received contrary instructions from one or more of the stockholders. This procedure reduces our printing and mailing costs. Stockholders who participate in

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householding will continue to be able to access and receive separate proxy cards. Upon written or oral request, we will promptly deliver a separate copy of the proxy materials and annual report to any stockholder at a shared address to which we delivered a single copy of any of these documents. To receive a separate copy, or, if you are receiving multiple copies, to request that we only send a single copy of next year’s proxy materials and annual report, you may contact us as follows:

Otonomy, Inc.

Attention: Secretary

4796 Executive Drive

San Diego, California 92121

(619)323-2200

Stockholders who hold shares in street name may contact their brokerage firm, bank, broker-dealer or other nominee to request information about householding.

How can I find out the results of the voting at the Annual Meeting?

Preliminary voting results will be announced at the Annual Meeting. In addition, final voting results will be published in a current report on Form8-K that we expect to file within four business days after the Annual Meeting. If final voting results are not available to us at that time, we intend to file a Form8-K to publish preliminary results and, within four business days after the final results are known to us, file an amendment to the Form8-K to publish the final results.

What is the deadline to propose actions for consideration at next year’s annual meeting of stockholders or to nominate individuals to serve as directors?

Stockholder Proposals

Stockholders may present proper proposals for inclusion in our proxy statement and for consideration at the next annual meeting of stockholders by submitting their proposals in writing to our Secretary in a timely manner. For a stockholder proposal to be considered for inclusion in our proxy statement for our 20212022 annual meeting of stockholders, our Secretary must receive the written proposal at our principal executive offices not later than January 6, 2021.2022. In addition, stockholder proposals must comply with the requirements of Rule14a-8 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), regarding the inclusion of stockholder proposals in company-sponsored proxy materials. Stockholder proposals should be addressed to:


Otonomy, Inc.

Attention: Secretary

4796 Executive Drive

San Diego, California 92121

Our bylaws also establish an advance notice procedure for stockholders who wish to present a proposal before an annual meeting of stockholders but do not intend for the proposal to be included in our proxy statement. Our bylaws provide that the only business that may be conducted at an annual meeting is business that is (i) specified in our proxy materials with respect to such meeting, (ii) otherwise properly brought before the annual meeting by or at the direction of the Board, or (iii) properly brought before the annual meeting by a stockholder of record entitled to vote at the annual meeting who has delivered timely written notice to our Secretary, which notice must contain the information specified in our bylaws. To be timely for our 20212022 annual meeting of stockholders, our Secretary must receive the written notice at our principal executive offices:

not earlier than February 19, 2021 18, 2022and

not later than March 22, 20212022

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In the event that we hold our 20212022 annual meeting of stockholders more than 30 days before or more than 60 days after the first anniversary of the date of the Annual Meeting, then notice of a stockholder proposal that is not intended to be included in our proxy statement must be received no earlier than the close of business on the 120th day before such annual meeting and no later than the close of business on the later of the following two dates:

the 90th day prior to such annual meeting;or

the 10th day following the day on which public announcement of the date of such annual meeting is firstmade.

If a stockholder who has notified us of his, her or its intention to present a proposal at an annual meeting does not appear to present his, her or its proposal at such annual meeting, we are not required to present the proposal for a vote at such annual meeting.

Nomination of Director Candidates

You may propose director candidates for consideration by our corporate governance and nominating committee. Any such recommendations should include the nominee’s name and qualifications for membership on our board of directors and should be directed to our Secretary at the address set forth above. For additional information regarding stockholder recommendations for director candidates, see “Board of Directors and Corporate Governance—Stockholder Recommendations for Nominations to the Board of Directors.”

In addition, our bylaws permit stockholders to nominate directors for election at an annual meeting of stockholders. To nominate a director, the stockholder must provide the information required by our bylaws. In addition, the stockholder must give timely notice to our Secretary in accordance with our bylaws, which, in general, require that the notice be received by our Secretary within the time period described above under “Stockholder Proposals” for stockholder proposals that are not intended to be included in a proxy statement.

Availability of Bylaws

A copy of our bylaws may be obtained by accessing our public filings on the SEC’s website at www.sec.gov. You may also contact our Secretary at our principal executive office for a copy of the relevant bylaw provisions regarding the requirements for making stockholder proposals and nominating director candidates.


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BOARD OF DIRECTORS AND CORPORATE GOVERNANCE

Our business affairs are managed under the direction of our board of directors, which is currently comprised of seven (7) members. Our board of directors has affirmatively determined that six (6) of our seven (7) directors, are independent within the meaning of the independent director requirements of The NASDAQ Stock Market LLC (“NASDAQ”). Our board of directors is divided into three classes with staggered three-year terms. At each annual meeting of stockholders, a class of directors will be elected for a three-year term to succeed the same class whose term is then expiring.

Upon the recommendation of our corporate governance and nominating committee, we are nominating Vickie Capps, Ciara Kennedy,James B. Breitmeyer, M.D., Ph.D., and Iain McGillDavid A. Weber, Ph.D. for election as Class IIII directors at the Annual Meeting. If elected, Ms. Capps, Dr. KennedyDrs. Breitmeyer and Mr. McGillWeber will each hold office for a three-year term until the annual meeting of stockholders to be held in 20232024 or until their successors are duly elected and qualified.

The following table sets forth the names, ages as of March 31, 20202021 and certain other information for the directors with terms expiring at the Annual Meeting (who are also nominees for election as a director at the Annual Meeting) and for each of the continuing directors:

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Expiration of

 

 

 

 

 

 

 

 

 

 

 

 

Current

 

Term For

 

 

 

 

 

 

 

 

 

 

Director

 

Term

 

Which

 

Name  Class   Age   

Position

  Director
Since
   Current
Term
Expires
   Expiration of
Term For
Which
Nominated
 

 

Class

 

Age

 

 

Position

 

Since

 

Expires

 

Nominated

 

1. Director Nominees

            

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

James B. Breitmeyer, M.D., Ph.D. (1)(2)

 

I

 

 

67

 

 

Director

 

2018

 

2021

 

2024

 

David A. Weber, Ph.D.

 

I

 

 

61

 

 

President, Chief Executive Officer and Director

 

2010

 

2021

 

2024

 

2. Continuing Directors

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Jay Lichter, Ph.D. (2)

 

II

 

 

59

 

 

Chairman of the Board

 

2008

 

2022

 

 

 

Theodore R. Schroeder (2)

 

II

 

 

66

 

 

Director

 

2015

 

2022

 

 

 

Vickie Capps (1)(3)

   III    58   Director   2014    2020    2023 

 

III

 

 

59

 

 

Director

 

2014

 

2023

 

 

 

Ciara Kennedy, Ph.D. (3)

   III    48   Director   2020    2020    2023 

 

III

 

 

49

 

 

Director

 

2020

 

2023

 

 

 

Iain McGill (1)(3)

   III    47   Director   2016    2020    2023 

 

III

 

 

48

 

 

Director

 

2016

 

2023

 

 

 

2. Continuing Directors

            

James B. Breitmeyer, M.D., Ph.D. (1)(2)

   I    66   Director   2018    2021    —   

David A. Weber, Ph.D.

   I    60   President, Chief Executive Officer and Director   2010    2021    —   

Jay Lichter, Ph.D. (2)

   II    58   Chairman of the Board   2008    2022    —   

Theodore R. Schroeder (2)

   II    65   Director   2015    2022    —   

 

(1)

Member of our auditcommittee

(2)

Member of our compensationcommittee

(3)

Member of our corporate governance and nominatingcommittee

Nominees for Director

James B. Breitmeyer, M.D., Ph.D. has served on our board of directors since June 2018. Since September 2015, Dr. Breitmeyer has served as President, Chief Executive Officer and director of Oncternal Therapeutics, Inc. a clinical-stage oncology biotechnology company. He has been a director of Zogenix, Inc., a pharmaceutical company, since March 2014, and was their acting Chief Medical Officer from August 2012 to February 2013.

Previously, Dr. Breitmeyer served as President of Bavarian Nordic, Inc. and Executive Vice President of Bavarian A/S, a multinational corporation headquartered in Denmark, from February 2013 to July 2015. He previously served as the Executive Vice President of Development and Chief Medical Officer of Cadence Pharmaceuticals Inc., a pharmaceutical company, from August 2006 to August 2012, and the Chief Medical Officer of Applied Molecular Evolution Inc., a wholly-owned subsidiary of Eli Lilly and Co., a global pharmaceutical company, from December 2001 to August 2006. Dr. Breitmeyer has also served as President and Chief Executive Officer of the Harvard Clinical Research Institute, and as Chief Medical Officer and Head of Research & Development for North America at Serono Laboratories Inc., an international biopharmaceutical company. Dr. Breitmeyer served as a founding collaborator and scientific advisor to Immunogen Inc., a biotechnology company, and held clinical and teaching positions at the Dana Farber Cancer Institute and Harvard Medical School. Dr. Breitmeyer earned his B.A. in Chemistry from the University of California and his M.D. and Ph.D. from Washington University School of Medicine and is Board Certified in Internal Medicine and Oncology.

We believe Dr. Breitmeyer is qualified to serve on our board of directors because of his extensive experience in the biopharmaceutical industry, including providing strong executive leadership to numerous biopharmaceutical companies, and significant expertise in the medical field.


David A. Weber, Ph.D. has served as our President and Chief Executive Officer and on our board of directors since November 2010. Prior to joining us, Dr. Weber served from February 2004 to April 2010 as the Chief Executive Officer of MacuSight, Inc., a developer of a sustained delivery formulation of sirolimus for the treatment of severe ophthalmic diseases. Prior to MacuSight, he served as acting Chief Executive Officer and Executive Vice President of Oculex Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of intraocular pharmaceuticals and drug delivery systems, until its acquisition by Allergan in 2003. Dr. Weber has also held management positions in healthcare product development with Oral-B Laboratories and The Procter & Gamble, Co., a consumer products company. From September 2018 to April 2021, he served on the board of directors of Oculis, a clinical stage ophthalmic biotechnology company. Dr. Weber received his Ph.D. in medical microbiology from Creighton University and his Master’s and Bachelor’s degrees in biological sciences from Wichita State University.

We believe Dr. Weber is qualified to serve on our board of directors because of his broad range of experience in business and healthcare product development, including over a decade as the chief executive officer of companies developing locally delivered therapeutics.

Continuing Directors

Vickie Cappshas served on our board of directors since March 2014. From July 2002 to December 2013, Ms. Capps was the Chief Financial Officer of DJO Global, Inc., a medical device company. Prior to joining DJO Global, Inc., Ms. Capps served as the Chief Financial Officer of several other public and private companies. Ms. Capps has served as a member of the board of directors of Amedisys Inc., a provider of home health and hospice services, since November 2019, and is a member of its audit committee, compensation committee and nominating and corporate governance committee, and of NuVasive, Inc., a medical device company, since June 2015, and is the chair of its audit committee and a member of its nominating, corporate governance and compliance committee. Since November 2019, she has also served as a member of the board of directors of Amedisys, Inc., a provider of home health and hospice services, and is the chair of its audit committee and a member of its compensation and nominating and corporate governance committees. Since May 2020, Ms. Capps has served as a member of the board of directors of Silverback Therapeutics, Inc., a biotechnology company, and is the chair of its audit committee and a member of its nominating and corporate governance committee. In addition, Ms. Capps serves as a member of the senior advisory board of Consonance Partners (CCP), a healthcare investment firm, and iswas a member of the board of directors of CCP’s portfolio company, Eagle Rx, Inc., a provider of pharmacy services to the hospice industry, until the sale of the company in January 2020. Ms. Capps was also a member of the board of directors of OmniGuide, Inc., a private medical device company. Ms. Capps previously served on the board of directors of Synthorx, Inc., a biotechnology company fromuntil December 2018 until its sale in January 2020, and of Connecture, Inc., a healthcare IT company, from October 2014 to April 2018. Ms. Capps has also previously served on the boards of directors of several other public and private companies, including RF Surgical Systems, Inc., Eagle Rx, Inc. and SenoRx, Inc.31, 2020. In addition, Ms. Capps serves as a member of the board of directors of the San Diego State University Research Foundation

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and is a member of its audit committee and its finance and investment committee. Ms. Capps previously served as a member of the board of directors of Synthorx, Inc., a biotechnology company, from April 2018 until the sale of the company in January 2020. Earlier in her career, Ms. Capps was a Senior Audit and Accounting Professional at Ernst & Young, LLP. Ms. Capps is a California Certified Public Accountant and was recognized as a CFO of the Year Honoree by the San Diego Business Journal in 2009 and 2010.  Ms. Capps holds a Bachelor’s degree in Business Administration/Accounting from San Diego State University.

We believe Ms. Capps is qualified to serve on our board of directors because of her exceptionally strong skill set consisting of corporate finance, accounting, operations, investor relations, capital markets and strategic business development.

Ciara Kennedy, Ph.D.has served on our board of directors since March 2020.  Since December 2016, Dr. Kennedy has served as President, Chief Executive Officer and director of Amplyx Pharmaceuticals, and previously served as the company’s Chief Operating Officer beginning in October 2015. Amplyx is a clinical-stage company developing innovative drug therapies for debilitating and life-threatening diseases in patients with compromised immune systems. Prior to Amplyx, she served as Chief Operating Officer at Lumena Pharmaceuticals, until the company’s acquisition by Shire Pharmaceuticals, and then continued as Vice President, Head of Cholestatic Liver Disease at Shire post acquisition. Previously, Dr. Kennedy held several positions at Cypress Bioscience where she played a key role in the company’s FDA approval and launch of Savella® for fibromyalgia, and also held several positions in program and alliance management at Biogen Idec where she managed multiple development projects spanning the drug discovery and development continuum. She is a founder of Reneo Pharmaceuticals and Mirum Pharmaceuticals, and also serves as a director of privately held Aristea Therapeutics. Dr. Kennedy received her doctorate at the Queen’s University of Belfast, Northern Ireland, her Master of Business Administration from the Rady School of Management at University of California, San Diego , and her Bachelor of Science from University Collegeof Cork, Ireland.

We believe Dr. Kennedy is qualified to serve on our board of directors because of her experience as an investor in biopharmaceutical and life sciences companies, her educational background, and her leadership in the medical and life science industries.

Iain McGillhas served on our board of directors since August 2016. Since June 2019, Mr. McGill has served as Chief Executive Officer and as a member of the board of directors of Quell Therapeutics, a cell and gene therapy company in the immune dysregulations field. From July 2010 to June 2019, Mr. McGill served in various positions at Jazz Pharmaceuticals plc, an international biopharmaceutical company, and, prior to its acquisition by Jazz Pharmaceuticals in 2012, EUSA Pharma, a specialty pharmaceutical company, including as Senior Vice President, Europe and Rest of World from March 2015 to June 2019, as Head of EUSA Pharma and Senior Vice President, Jazz Pharmaceuticals from March 2014 to March 2015, and as Chief Commercial Officer, EUSA Pharma, from June 2012 to March 2014. From 2006 to 2009, Mr. McGill served as Vice President and Global Business Manager for Transplantation and Immunology at Wyeth, a pharmaceutical company acquired by Pfizer Inc. Mr. McGill holds a Bachelor of Science degree in Biochemistry from the University of London.

We believe Mr. McGill is qualified to serve on our board of directors because of his leadership experience in the biotechnology and pharmaceutical industries.

Continuing Directors

James B. Breitmeyer, M.D., Ph.D.has served on our board of directors since June 2018. Since September 2015, Dr. Breitmeyer has served as President, Chief Executive Officer and director of Oncternal Therapeutics, Inc. a clinical-stage oncology biotechnology company. He has been a director of Zogenix, Inc., a pharmaceutical company, since March 2014, and was their acting Chief Medical Officer from August 2012 to February 2013. Previously, Dr. Breitmeyer served as President of Bavarian Nordic, Inc. and Executive Vice President of Bavarian A/S, a multinational corporation headquartered in Denmark, from February 2013 to July 2015. He previously served as the Executive Vice President of Development and Chief Medical Officer of Cadence Pharmaceuticals Inc., a pharmaceutical company, from August 2006 to August 2012, and the Chief Medical

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Officer of Applied Molecular Evolution Inc., a wholly-owned subsidiary of Eli Lilly and Co., a global pharmaceutical company, from December 2001 to August 2006. Dr. Breitmeyer has also served as President and Chief Executive Officer of the Harvard Clinical Research Institute, and as Chief Medical Officer and Head of Research & Development for North America at Serono Laboratories Inc., an international biopharmaceutical company. Dr. Breitmeyer served as a founding collaborator and scientific advisor to Immunogen Inc., a biotechnology company, and held clinical and teaching positions at the Dana Farber Cancer Institute and Harvard Medical School. Dr. Breitmeyer earned his B.A. in Chemistry from the University of California and his M.D. and Ph.D. from Washington University School of Medicine and is Board Certified in Internal Medicine and Oncology.

We believe Dr. Breitmeyer is qualified to serve on our board of directors because of his extensive experience in the biopharmaceutical industry, including providing strong executive leadership to numerous biopharmaceutical companies, and significant expertise in the medical field.

David A. Weber, Ph.D.has served as our President and Chief Executive Officer and on our board of directors since November 2010. Prior to joining us, Dr. Weber served from February 2004 to April 2010 as the Chief Executive Officer of MacuSight, Inc., a developer of a sustained delivery formulation of sirolimus for the treatment of severe ophthalmic diseases. Prior to MacuSight, Dr. Weber served as acting Chief Executive Officer and Executive Vice President of Oculex Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the development and commercialization of intraocular pharmaceuticals and drug delivery systems, until its acquisition by Allergan in 2003. Dr. Weber has also held management positions withOral-B Laboratories, a developer and manufacturer of oral hygiene products, and with Procter & Gamble, Co., a consumer products company. Dr. Weber has served on the board of directors of Oculis, a clinical stage ophthalmic biotechnology company, since September 2018. From October 2009 to July 2014, Dr. Weber served on the board of directors of On Demand Therapeutics, Inc., a medical device company. Dr. Weber received his Ph.D. in medical microbiology from Creighton University and his Master’s and Bachelor’s degrees in biological sciences from Wichita State University.

We believe Dr. Weber is qualified to serve on our board of directors because of his broad range of experience in business and healthcare product development, including over a decade as the chief executive officer of companies developing locally delivered therapeutics.

Jay Lichter, Ph.D.has served on our board of directors since May 2008 and Chairman of our board of directors since August 2015. Dr. Lichter served as our Chief Executive Officer from inception until November 2010. Dr. Lichter is currently chief executive officer of Avelas BioSciences and Fortis, both private biotechnology companies. He is an experienced biotechnology and pharmaceutical business executive with over 25 years of experience in management, scientific research and business development. Since 2007, Dr. Lichter has been a managing director at Avalon Ventures, an early-stage venture capital fund focused on information technology and life sciences. In that role, he led Avalon’s investments in public companies SynthoRx,Synthorx, Inc. and Aratana Therapeutics, Inc., and served as a director and chief executive


officer for several privately-held biotechnology companies. He previously served on the board of directors of Aratana Therapeutics,Synthorx, Inc., a public pharmaceutical from January 2014 until the sale of the company from December 2010 to August 2015, and on the board of directors of SynthoRx, Inc., a biotechnology company, from February 2014 toin January 2020. Dr. Lichter also led Avalon’s investments in or currently serves on the board of several privately-held companies, including AristaMD, Fortis Therapeutics, Inc., Avelas BioSciences, Inc., COI Pharmaceuticals Inc., Sitari Pharmaceuticals Corp. and Sova Pharmaceuticals, Inc.Janux Therapeutics., among other life science companies. Dr. Lichter received a Bachelor’s degree and Ph.D. in biochemistry from the University of Illinois. He also completed post-doctoral fellowships at Yale University and Du Pont Merck Pharmaceutical Company.

We believe Dr. Lichter is qualified to serve on our board of directors because of his experience as a venture capital investor and his experience as a biotechnology and pharmaceutical business executive with over 25 years of experience in management, scientific research and development.

Iain McGill has served on our board of directors since August 2016. Mr. McGill currently serves as Senior Vice President of Jazz Pharmaceuticals Europe and Rest of World for Jazz Pharmaceuticals Public Limited Company, an international biopharmaceutical company, since March 2015. From March 2014 to March 2015, Mr. McGill served as Head of EUSA Pharma and Senior Vice President, Jazz Pharmaceuticals, and as Chief Commercial Officer, EUSA Pharma, a specialty pharmaceutical company, from June 2012 to March 2014, when he joined Jazz Pharmaceuticals in connection with its acquisition of EUSA Pharma. From October 2011 to June 2012, Mr. McGill served as Chief Commercial Officer at EUSA Pharma (Europe) Ltd. From August 2010 to September 2011, he served as President Europe, International & Global Marketing of EUSA Pharma (Europe) Ltd, and from January 2010 to July 2010, as President of Europe. From 2006 to 2009, Mr. McGill served as Vice President and Global Business Manager at Wyeth, a pharmaceutical company acquired by Pfizer Inc. Mr. McGill holds a Bachelor of Science degree in Biochemistry from the University ofLondon.

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We believe Mr. McGill is qualified to serve on our board of directors because of his leadership experience in the biotechnology and pharmaceutical industries.


Theodore R. Schroederhas served on our board of directors since August 2015. Since July 2018, Mr. Schroeder has served as Chief Executive Officer and as a member of the board of directors of Nabriva Therapeutics plc, a biopharmaceutical company. Previously, Mr. Schroeder served as President, Chief Executive Officer and as a member of the board of directors of Zavante Therapeutics, Inc., a private biopharmaceutical company, from June 2015 to July 2018. Mr. Schroederco-founded Cadence Pharmaceuticals, Inc., a formerly- public pharmaceutical company, and served as its President and Chief Executive Officer, and as a member of the board of directors, from May 2004 until its acquisition in March 2014 by Mallinckrodt Pharmaceuticals, Inc.  Prior to this, Mr. Schroeder held a number of hospital-related sales and marketing positions with Elan, Dura Pharmaceuticals and Bristol-Myers Squibb Company, a global pharmaceutical company. Mr. Schroeder currently serveshas served on the board of directors of Cidara Therapeutics, Inc., a public biotechnology company, since April 2014 and Collegium Pharmaceuticals, a public specialty pharmaceutical company, and previously served on the board of directors of Biocom, a regional life science trade association.since January 2016. Mr. Schroeder holds a Bachelor’s degree in management from Rutgers University.

We believe Mr. Schroeder is qualified to serve on our board of directors because of his leadership and broad range of experience in pharmaceutical and life sciences companies.

Director Independence

Our common stock is listed on The NASDAQ Global Select Market. Under the rules of NASDAQ, independent directors must comprise a majority of a listed company’s board of directors. In addition, the rules of NASDAQ require that, subject to specified exceptions, each member of a listed company’s audit, compensation and nominating and governance committees be independent. Audit committee members and compensation committee members must also satisfy the independence criteria set forth in Rule10A-3 and Rule10C-1, respectively, under the Exchange Act. Under the rules of NASDAQ, a director will only qualify as an “independent director” if, in the opinion of that company’s board of directors, that person does not have a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director.

To be considered independent for purposes of Rule10A-3 and under the rules of NASDAQ, a member of an audit committee of a listed company may not, other than in his or her capacity as a member of our audit committee, our board of directors, or any other board committee: (i) accept, directly or indirectly, any consulting, advisory, or other compensatory fee from the listed company or any of its subsidiaries; or (ii) be an affiliated person of the listed company or any of its subsidiaries.

To be considered independent for purposes of Rule10C-1 and under the rules of NASDAQ, the board of directors must affirmatively determine that the member of the compensation committee is independent, including a consideration of all factors specifically relevant to determining whether the director has a relationship to the company which is material to that director’s ability to be independent from management in connection with the duties of a compensation committee member, including, but not limited to: (i) the source of compensation of such director, including any consulting, advisory or other compensatory fee paid by the company to such director; and (ii) whether such director is affiliated with the company, a subsidiary of the company or an affiliate of a subsidiary of the company.


Our board of directors has undertaken a review of its composition, the composition of its committees and the independence of our directors and considered whether any director has a material relationship with us that could compromise his or her ability to exercise independent judgment in carrying out his or her responsibilities. Based upon information requested from and provided by each director concerning his background, employment and affiliations, including family relationships, our board of directors has determined that none of Messrs. McGill and Schroeder, Drs. Breitmeyer, Kennedy and Lichter, ,Messrs. McGill and Schroeder, and Ms. Capps, representing six of our seven current directors, has a relationship that would interfere with the exercise of independent judgment in carrying out the responsibilities of a director, and that each of these directors is “independent” as that term is

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defined under the rules of NASDAQ. Our board of directors also determined that Ms. Capps (chairperson), Dr. Breitmeyer and Mr. McGill, who currently comprise our audit committee, and Mr. Schroeder (chairperson) and Drs. Breitmeyer and Lichter, who currently comprise our compensation committee, satisfy the independence standards for committee members established by applicable SEC rules and the listing standards of NASDAQ.

In making these determinations, our board of directors considered the current and prior relationships that eachnon-employee director has with our company and all other facts and circumstances our board of directors deemed relevant in determining their independence, including the beneficial ownership of our capital stock by eachnon-employee director, and the transactions involving them described in the section titled “Related Party Transactions.”

There are no family relationships among any of our directors or executive officers.

Board Leadership Structure

Our board of directors is currently chaired by Dr. Lichter. As a general policy, our board of directors believes that separation of the positions of Chairman and Chief Executive Officer reinforces the independence of the board of directors from management, creates an environment that encourages objective oversight of management’s performance and enhances the effectiveness of the board of directors as a whole. As such, Dr. Weber serves as our President and Chief Executive Officer while Dr. Lichter serves as our Chairman of the board of directors but is not an officer. We expect and intend the positions of Chairman of the board of directors and Chief Executive Officer to continue to be held by two individuals in the future.

Board Meetings and Committees

During 2019,2020, our board of directors held four meetings (including regularly scheduled and special meetings), and each director attended at least 75% of the aggregate of (i) the total number of meetings of our board of directors held during the period for which he or she served as a director and (ii) the total number of meetings held by all committees of our board of directors on which he or she served during the periods that he or she served.

It is the policy of our board of directors to regularly have separate meeting times for independent directors without management. Although we do not have a formal policy regarding attendance by members of our board of directors at annual meetings of stockholders, we encourage, but do not require, our directors to attend. FourAll of our directors then serving on our board of directors attended our 20192020 annual meeting of stockholders.

We have established an audit committee, a compensation committee and a corporate governance and nominating committee. We believe that the composition of these committees will meet the criteria for independence under, and the functioning of these committees comply with the requirements of, the Sarbanes-Oxley Act of 2002, the rules of the NASDAQ Global Select Market and SEC rules and regulations. We intend to comply with the requirements of the NASDAQ Global Select Market with respect to committee composition of independent directors. Each committee has the composition and responsibilities described below.

Audit Committee

The members of our audit committee are Ms. Capps, Dr. Breitmeyer and Mr. McGill, each of whom is anon-employee member of our board of directors. Ms. Capps serves as the chairperson of our audit committee. All members of our audit committee meet the requirements for independence and financial literacy of audit committee members under current NASDAQ listing standards and SEC rules and regulations. Our audit committee chairperson, Ms. Capps, is our audit committee financial expert, as that term is defined under the SEC rules implementing Section 407 of the Sarbanes-Oxley Act of 2002, and possesses financial sophistication, as

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defined under NASDAQ listing standards. The responsibilities of our audit committee include, among other things:

selecting and hiring the independent registered public accounting firm to audit our financialstatements;

helping to ensure the independence and performance of the independent registered public accounting firm;

approving audit andnon-audit services andfees;


 

reviewing financial statements and discussing with management and the independent registered public accounting firm our annual audited and quarterly financial statements, the results of the independent audit and the quarterly reviews, and the reports and certifications regarding internal controls over financial reporting and disclosurecontrols;

preparing the audit committee report that the SEC requires to be included in our annual proxy statement;

reviewing reports and communications from the independent registered public accountingfirm;

reviewing the adequacy and effectiveness of our internal controls and disclosure controls and procedures;

reviewing our policies on risk assessment and riskmanagement;

reviewing related party transactions;and

establishing and overseeing procedures for the receipt, retention and treatment of accounting related complaints and the confidential submission by our employees of concerns regarding questionable accounting or auditingmatters.

Our audit committee operates under a written charter that satisfies the applicable rules and regulations of the SEC and the listing requirements of NASDAQ. A copy of the charter of our audit committee is available on our website at http://investors.otonomy.com in the Corporate Governance section of our Investor Relations webpage. During 2019,2020, our audit committee held five meetings.

Compensation Committee

The members of our compensation committee are Mr. Schroeder and Drs. Breitmeyer and Lichter. Mr. Schroeder serves as the chairperson of our compensation committee.  All members of our compensation committee meet the requirements for independence under current NASDAQ listing standards and SEC rules and regulations. Each member of our compensation committee is also anon-employee director, as defined pursuant to Rule16b-3 promulgated under the Exchange Act. The purpose of our compensation committee is to oversee our compensation policies, plans and benefit programs and to discharge the responsibilities of our board of directors relating to compensation of our executive officers. The responsibilities of our compensation committee include, among other things:

overseeing our overall compensation philosophy and compensation policies, plans and benefit programs;

reviewing and approving or recommending to the board for approval compensation for our executive officers anddirectors;

preparing the compensation committee report that the SEC will require to be included in our annual proxy statement;and

administering our equity compensationplans.

Our compensation committee operates under a written charter that satisfies the listing standards of NASDAQ. A copy of the charter of our compensation committee is available on our website at

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http://investors.otonomy.com in the Corporate Governance section of our Investor Relations webpage. During 2019,2020, our compensation committee held five meetings.

Corporate Governance and Nominating Committee

The members of our corporate governance and nominating committee are Mr. McGill, Ms. Capps and Dr. Kennedy (appointment effective March 1, 2020).Kennedy. Mr. McGill serves as the chairperson of our corporate governance and nominating committee. Dr. Preston served as a member of our corporate governance and nominating committee until February 28, 2020. All members of our corporate governance and nominating committee meet the requirements for independence under current NASDAQ listing standards and SEC rules and regulations. The responsibilities of our corporate governance and nominating committee include, among other things:

identifying, evaluating and making recommendations to our board of directors regarding nominees for election to our board of directors and itscommittees;

considering and making recommendations to our board of directors regarding the composition of our board of directors and itscommittees;

reviewing developments in corporate governancepractices;

evaluating the adequacy of our corporate governance practices and reporting;and

evaluating the performance of our board of directors and of individualdirectors.

Our corporate governance and nominating committee operates under a written charter that satisfies the listing standards of NASDAQ. A copy of the charter of our corporate governance and nominating committee is available on our website at http://investors.otonomy.com in the Corporate Governance section of our Investor Relations webpage. During 2019,2020, our corporate governance and nominating committee held three meetings.


Compensation Committee InterlocksInterlocks and Insider Participation

During the past fiscal year, Mr. Schroeder and Drs. Breitmeyer and Lichter served on our compensation committee. None of the members of our compensation committee is or has at any time beenwas during 2020 an officer or was during 2019 an employee of our company. None of our executive officers currently serves, or in the past year has served, as a member of our board of directors or compensation committee (or other board committee performing equivalent functions) of any entity that has one or more of its executive officers serving on our board of directors or compensation committee.

Considerations in Evaluating Director Nominees

It is the policy of the corporate governance and nominating committee of our board of directors to consider recommendations for candidates to our board of directors from stockholders holding not less than one percent (1%) of the outstanding shares of the Company’s common stock continuously for at least twelve (12) months prior to the date of the submission of the recommendation or nomination.

The corporate governance and nominating committee will use the following procedures to identify and evaluate any individual recommended or offered for nomination to our board of directors:

The corporate governance and nominating committee will consider candidates recommended by stockholders in the same manner as candidates recommended to the corporate governance and nominating committee from othersources.

In its evaluation of director candidates, including the members of our board of directors eligible forre-election, the corporate governance and nominating committee will consider thefollowing:

The current size and composition of our board of directors and the needs of our board of directors and the respective committees of our board ofdirectors.

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Such factors as character, integrity, judgment, diversity of experience, independence, area of expertise, corporate experience, length of service, potential conflicts of interest, other commitments (including but not limited to other board, committee and employment commitments, as applicable), and the like. The corporate governance and nominating committee evaluates these factors, among others, and does not assign any particular weighting or priority to any of these factors.

Other factors that the corporate governance and nominating committee deemsappropriate.

Although we do not maintain a specific policy with respect to board diversity, ourOur board of directors believes that our board of directors should be a diverse body, and our corporate governance and nominating committee considers a broad range of backgrounds and experiences. InAlthough we do not maintain a specific policy with respect to board diversity, in making determinations regarding nominations of directors, our corporate governance and nominating committee takes into account the benefits of diverse viewpoints.

The corporate governance and nominating committee requires the following minimum qualifications to be satisfied by any nominee for a position on our board ofdirectors:

The highest personal and professional ethics andintegrity.

Proven achievement and competence in the nominee’s field and the ability to exercise sound businessjudgment.

Skills that are complementary to those of the existing board ofdirectors.

The ability to assist and support management and make significant contributions to the Company’s success.

An understanding of the fiduciary responsibilities that is required of a member of our board of directors and the commitment of time and energy necessary to diligently carry out those responsibilities.

If the corporate governance and nominating committee determines that an additional or replacement director is required, the corporate governance and nominating committee may take such measures that it considers appropriate in connection with its evaluation of a director candidate, including candidate interviews, inquiry of the person or persons making the recommendation or nomination, engagement of an outside search firm to gather additional information, or reliance on the knowledge of the members of the corporate governance and nominating committee, our board directors ormanagement.

The corporate governance and nominating committee may propose to our board of directors a candidate recommended or offered for nomination by a stockholder as a nominee for election to our board of directors. Additionally, the corporate governance and nominating committee has in the past, and may again in the future, pay fees to third parties to assist in identifying or evaluating director candidates.

Annually the board of directors conducts a review and assessment regarding the peformance and effectiveness of the board of directors and each of the committees and evaluates opportunities to improve performace and effectiveness.


Stockholder Recommendations for NominationsNominations to the Board of Directors

A stockholder that wants to recommend a candidate for election to our board of directors should direct the recommendation in writing by letter to the Company, attention of the Secretary, at 4796 Executive Drive, San Diego, California 92121. The recommendation must include the candidate’s name, home and business contact information, detailed biographical data, relevant qualifications, a signed letter from the candidate confirming willingness to serve, information regarding any relationships between the candidate and the Company and evidence of the recommending stockholder’s ownership of Company stock. Such recommendations must also include a statement from the recommending stockholder in support of the candidate, particularly within the context of the criteria for board membership, including issues of character, integrity, judgment, diversity of experience, independence, area of expertise, corporate experience, length of service, potential conflicts of interest, other commitments and the like and personal references.

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A stockholder that instead desires to nominate a person directly for election to our board of directors at an annual meeting of the stockholders must meet the deadlines and other requirements set forth in Section 2.4 of the Company’s bylaws and the rules and regulations of the SEC. Section 2.4 of the Company’s bylaws requires that a stockholder who seeks to nominate a candidate for director must provide a written notice to the Secretary of the Company not later than the 45th day nor earlier than the 75th day before theone-year anniversary of the date on which the corporation first mailed its proxy materials or a notice of availability of proxy materials (whichever is earlier) for the preceding year’s annual meeting;provided,however, that in the event that no annual meeting was held in the previous year or if the date of the annual meeting is advanced by more than 30 days prior to or delayed by more than 60 days after theone-year anniversary of the date of the previous year’s annual meeting, then notice by the stockholder to be timely must be so received by the Secretary of the Company not earlier than the close of business on the 120th day prior to such annual meeting and not later than the close of business on the later of (i) the 90th day prior to such annual meeting and (ii) the 10th day following the day on which Public Announcement (as defined below) of the date of such annual meeting is first made. That notice must state the information required by Section 2.4 of the Company’s bylaws, and otherwise must comply with applicable federal and state law. The Secretary of the Company will provide a copy of the bylaws upon request in writing from a stockholder. “Public Announcement” shall mean disclosure in a press release reported by the Dow Jones News Service, Associated Press or a comparable national news service or in a document publicly filed by the corporation with the SEC pursuant to Section 13, 14 or 15(d) of the Exchange Act, or any successor thereto.

Communications with the Board of Directors

Our board of directors believes that management speaks for Otonomy, Inc. Individual board members may, from time to time, communicate with various constituencies that are involved with the Company, but it is expected that board members would do this with knowledge of management and, in most instances, only at the request of management.

In cases where stockholders and other interested parties wish to communicate directly with ournon-management directors, messages can be sent to our Secretary, at Otonomy, Inc., 4796 Executive Drive, San Diego, California 92121, Attn: Secretary. Our Secretary monitors these communications and will provide a summary of all received messages to the board of directors at each regularly scheduled meeting of the board of directors. Our board of directors generally meets on a quarterly basis. Where the nature of a communication warrants, our Secretary may determine, in his or her judgment, to obtain the more immediate attention of the appropriate committee of the board ornon-management director, of independent advisors or of Company management, as our Secretary considers appropriate.

Our Secretary may decide in the exercise of his or her judgment whether a response to any stockholder or interested party communication is necessary.

This procedure for stockholder and other interested party communications with thenon-management directors is administered by our corporate governance and nominating committee. This procedure does not apply to (a) communications tonon-management directors from officers or directors of the Company who are stockholders, (b) stockholder proposals submitted pursuant to Rule14a-8 under the Exchange Act, or (c) communications to the audit committee pursuant to the Complaint Procedures for Accounting and Auditing Matters.

Corporate Governance Guidelines and Code of Business Conduct and Ethics

Our board of directors has adopted Corporate Governance Guidelines. These guidelines address items such as the qualifications and responsibilities of our directors and director candidates and corporate governance policies and standards applicable to us in general. In addition, our board of directors has adopted a Code of Ethics and Conduct that applies to all of our employees, officers and directors, including our Chief Executive Officer, Chief Financial and Business Officer, and other executive and senior financial officers. The full text of our

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Corporate Governance Guidelines and our Code of Ethics and Conduct is posted on our website at http://investors.otonomy.com in the Corporate Governance section of our Investor Relations webpage. We intend to post any amendments to our Code of Ethics and Conduct, and any waivers of our Code of Ethics and Conduct for directors and executive officers, on the same website.


Role of the Board in Risk Oversight

One of the key functions of our board of directors is informed oversight of our risk management process.

Our board of directors does not have a standingadministers oversight of the risk management committee, but rather administers this oversight function directly through the board of directors as a whole, as well as through its standing committees that address risks inherent in their respective areas of oversight. In particular, our board of directors is responsible for monitoring and assessing strategic risk exposure. Our audit committee is responsible for reviewing and discussing our major financial risk exposures and the steps our management has taken to monitor and control these exposures, including guidelines and policies with respect to risk assessment and risk management. Our audit committee also monitors compliance with legal and regulatory requirements and reviews related party transactions, in addition to oversight of the performance of our external audit function. Our corporate governance and nominating committee monitors the effectiveness of our corporate governance guidelines. Our compensation committee assesses and monitors whether any of our compensation policies and programs hashave the potential to encourage excessive risk-taking.

Director Compensation

Eachnon-employee director is eligible to receive compensation for his or her service consisting of annual cash retainers and equity awards as described below. We also reimburse our directors for expenses associated with attending meetings of our board of directors and committees of our board of directors.

Our compensation committee has the primary responsibility for reviewing and approving the compensation paid tonon-employee directors.  Our compensation committee reviews at least annually the type and form of compensation paid to ournon-employee directors, which includes a market assessment and analysis by our independent compensation consulting firm, Radford, regarding practices at comparable companies.  As part of this analysis, Radford reviewsnon-employee director compensation trends and data from companies comprising the same peer group used by our compensation committee in connection with its review of executive compensation. Based on this review, our compensation committee recommended and our board of directors approvedhas made adjustments to thenon-employee director compensation program, most recently in April 2020, in an effort to provide competitive compensation opportunities for ournon-employee directors.

Cash Compensation

Allnon-employee directors are entitled to receive the following cash compensation for their services:

$40,000 (or before the adjustment in April 2020, $35,000) per year for service as a boardmember;

$30,000 (or before the adjustment in April 2020, $20,000) per year for service as chairpersonchairman of theboard;

$15,000 per year for service as chairperson of the auditcommittee;

$7,500 per year for service as an audit committeemember;

$11,000 (or before the adjustment in April 2020, $10,000) per year for service as chairperson of the compensationcommittee;

$5,500 (or before the adjustment in April 2020, $5,000) per year  for service as a compensation committeemember;

$7,500 per year for service as chairperson of the corporate governance and nominating committee;and

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$4,000 (or before the adjustment in April 2020, $3,750) per year for service as a corporate governance and nominating committeemember.

All cash payments tonon-employee directors will be paid quarterly in arrears on a prorated basis.

Equity Compensation

Allnon-employee directors are entitled to receive the following equity compensation for their services:

Eachnon-employee director is automatically granted an initial award of a nonstatutory stock option to purchase 35,000 shares of our common stock effective on the date on which such person first becomesbecame elected as anon-employee director. On the date of each annual meeting of our stockholders, eachnon-employee director who had been anon-employee director for three months or more on the date of the annual meeting iswas automatically granted a nonstatutory stock option to purchase 17,500 shares of our common stock. The initial award will vest as toone-third of the shares subject thereto on each anniversary of the initial award’s grant date, provided that the director remains a service provider through the applicable vesting date. Each annual award will vest fully on the earlier of the anniversary date of the grant or the date of the next annual meeting held after the date of grant, provided that the director remains a service provider through the applicable vesting date. Prior to April 1, 2020, annual awards vested on the date of the next annual meeting held after the date of grant, provided that the director remained a service provider through the applicable vesting date.


Our 2014 Equity Incentive Plan (the “2014 Plan”) provides that in the event of a merger or change in control, as defined in the 2014 Plan, each outstanding equity award granted under the 2014 Plan that is held by anon-employee director will fully vest and all of the shares subject to such award will become fully exercisable, if applicable.

The following table sets forth information regarding compensation earned by or paid to ournon-employee directors during 2019:

Name

  Fees Earned
or Paid in
Cash ($)
   Option
Awards ($)(1)(2)
   Total ($) 

James Breitmeyer, M.D., Ph.D.

   47,500    31,511    79,011 

Vickie Capps

   53,750    31,511    85,261 

Jay Lichter, Ph.D.

   60,000    31,511    91,511 

Iain McGill

   50,000    31,511    81,511 

Heather Preston, M.D. (3)

   38,750    31,511    70,261 

Theodore R. Schroeder

   45,000    31,511    76,511 

(1)

This column reflects the aggregate grant date fair value of stock options granted during 2019 computed in accordance with the provisions of Accounting Standards Codification (ASC) 718, Compensation—Stock Compensation. The assumptions that we used to calculate these amounts are discussed in Note 11 to our audited financial statements for the year ended December 31, 2019 included in our Annual Report on Form10-K for the year ended December 31, 2019. These amounts do not reflect the actual economic value that will be realized by the director upon the vesting of the stock options, the exercise of the stock options, or the sale of the common stock underlying such stock options.

(2)

As of December 31, 2019, ournon-employee directors held outstanding options to purchase the number of shares of common stock as follows: Dr. Breitmeyer (52,500 shares), Ms. Capps (80,000 shares); Dr. Lichter (80,000 shares); Mr. McGill (75,000 shares); Dr. Preston (80,000 shares); and Mr. Schroeder (90,000 shares).

(3)

Dr. Preston served as a member of our board of directors until February 28, 2020.

See “Executive Compensation” for information about the compensation of directors who are also our employees.

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PROPOSAL NO. 1

ELECTION OF DIRECTORS

Our board of directors is currently composed of seven (7) members. In accordance with our certificate of incorporation, our board of directors is divided into three classes with staggered three-year terms. At the Annual Meeting, three Class III directors will be elected for a three-year term to succeed the same class whose term is then expiring.

Each director’s term continues until the election and qualification of such director’s successor, or such director’s earlier death, resignation, or removal. Any increase or decrease in the number of directors will be distributed among the three classes so that, as nearly as possible, each class will consist ofone-third of our directors. This classification of our board of directors may have the effect of delaying or preventing changes in control of our company.

Nominees

Our corporate governance and nominating committee has recommended, and our board of directors has approved Vickie Capps, Ciara Kennedy, Ph.D. and Iain McGill as nominees for election as Class III directors at the Annual Meeting. If elected, each of Ms. Capps, Dr. Kennedy and Mr. McGill will serve as Class III directors until the 2023 annual meeting of stockholders or until their successors are duly elected and qualified. Ms. Capps, Dr. Kennedy and Mr. McGill are currently directors of our company, and each has agreed to being named in this proxy statement as nominees. For information concerning the nominees, please see “Board of Directors and Corporate Governance.”

If you are a stockholder of record and you sign your proxy card or vote over the Internet or by telephone but do not give instructions with respect to the voting of directors, your shares will be voted FOR the election of Ms. Capps, Dr. Kennedy and Mr. McGill. We expect that Ms. Capps, Dr. Kennedy and Mr. McGill will accept such nomination; however, in the event that a director nominee is unable or declines to serve as a director at the time of the Annual Meeting, the proxies will be voted for any nominee who shall be designated by our board of directors to fill such vacancy. If you are a beneficial owner of shares of our common stock and you do not give voting instructions to your broker, bank or other nominee, then your broker, bank or other nominee will leave your shares unvoted on this matter.

Vote Required

The election of Class III directors requires a plurality vote of the shares of our common stock present in person or by proxy at the Annual Meeting and entitled to vote thereon to be approved. Brokernon-votes will have no effect on this proposal.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE ELECTION OF EACH OF THE THREE DIRECTORS NOMINATED BY OUR BOARD OF DIRECTORS AND NAMED IN THIS PROXY STATEMENT AS CLASS III DIRECTORS TO SERVE FOR A THREE-YEAR TERM.

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PROPOSAL NO. 2

ADVISORY VOTE ON THE COMPENSATION

OF OUR NAMED EXECUTIVE OFFICERS

In accordance with the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010 (the “Dodd-Frank Act”) and SEC rules, we are providing our stockholders with the opportunity to vote to approve, on an advisory ornon-binding basis, the compensation paid to our named executive officers as disclosed in this proxy statement pursuant to Section 14A of the Exchange Act. This proposal, commonly known as a“Say-on-Pay” proposal, gives our stockholders the opportunity to express their views on our named executive officers’ compensation as a whole. This vote is not intended to address any specific item of compensation or any specific named executive officer, but rather the overall compensation of all of our named executive officers and the philosophy, policies and practices described in this proxy statement.

TheSay-on-Pay vote is advisory, and therefore is not binding on us, our compensation committee, or our board of directors. TheSay-on-Pay vote will, however, provide information to us regarding investor sentiment about our executive compensation philosophy, policies and practices, which our compensation committee will be able to consider when determining executive compensation for the remainder of the current fiscal year and beyond. Our board of directors and our compensation committee value the opinions of our stockholders. Accordingly, our board of directors and our compensation committee will consider the outcome of this vote when making future compensation decisions for our named executive officers.

We believe that the information provided in the section titled “Executive Compensation” demonstrates that our executive compensation program was designed appropriately and is working to ensure management’s interests are aligned with our stockholders’ interests to support long-term value creation. Accordingly, we ask our stockholders to vote “FOR” the following resolution at the Annual Meeting:

“RESOLVED, that the stockholders approve, on anon-binding advisory basis, the compensation paid to our named executive officers, as disclosed in the proxy statement for the Annual Meeting pursuant to the compensation disclosure rules of the SEC, including the compensation tables and narrative discussion and other related disclosure.”

Vote Required

The approval of, on anon-binding advisory basis, the compensation paid to our named executive officers, requires the affirmative vote of a majority of the voting power of the shares of our common stock present in person or by proxy at the Annual Meeting and entitled to vote thereon to be approved. Abstentions will have the effect of a vote against this proposal, and brokernon-votes will have no effect.

As an advisory vote, the result of this proposal isnon-binding. Although the vote isnon-binding, our board of directors and our compensation committee value the opinions of our stockholders and will consider the outcome of the vote when making future compensation decisions for our named executive officers.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE APPROVAL OF, ON ANON-BINDING ADVISORY BASIS, THE COMPENSATION PAID TO OUR NAMED EXECUTIVE OFFICERS, AS DISCLOSED IN THIS PROXY STATEMENT.

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PROPOSAL NO. 3

ADVISORY VOTE ON THE FREQUENCY OF FUTURENON-BINDING STOCKHOLDER ADVISORY VOTES TO APPROVE THE COMPENSATION PAID TO OUR NAMED EXECUTIVE OFFICERS

In accordance with the Dodd-Frank Act and SEC rules, at least once every six years, we must provide our stockholders with the opportunity to indicate their preference regarding how frequently we should hold theSay-on-Pay vote. Accordingly, we are asking our stockholders to indicate whether they would prefer anon-binding advisory vote every one year, two years or three years. Alternatively, stockholders may abstain from casting a vote.

After considering the benefits and consequences of each alternative, our board of directors recommends that theSay-on-Pay vote be submitted to the stockholders every year. In formulating its recommendation, our board of directors considered that compensation decisions are made annually and that an annual advisory vote on the compensation of our named executive officers will allow stockholders to provide more frequent and direct input on our compensation philosophy, policies and practices.

Vote Required

The option among one year, two years or three years that receives the highest number of votes cast at the Annual Meeting by stockholders entitled to vote thereon will be deemed to be the frequency preferred by our stockholders. Abstentions and brokernon-votes will have no effect on this proposal.

While our board of directors believes that its recommendation is appropriate at this time, the stockholders are not voting to approve or disapprove that recommendation, but are instead asked to indicate their preference, on an advisory basis, as to whether futurenon-binding stockholder advisory votes to approve the compensation paid to our named executive officers should be held every one year, two years or three years.

As an advisory vote, the result of this proposal isnon-binding. Although the vote isnon-binding, our board of directors and our compensation committee value the opinions of our stockholders in this matter and, to the extent there is any significant vote in favor of one time period over another, will consider the outcome of this vote when making future decisions regarding the frequency of holding future stockholder advisory votes on the compensation of our named executive officers.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE TO HOLD FUTURENON-BINDING STOCKHOLDER ADVISORY VOTES TO APPROVE THE COMPENSATION PAID TO OUR NAMED EXECUTIVE OFFICERS EVERY “ONE YEAR.”

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PROPOSAL NO. 4

RATIFICATION OF APPOINTMENT OF

INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Our audit committee has appointed Ernst & Young LLP, as our independent registered public accounting firm to audit our financial statements for our fiscal year ending December 31, 2020. Ernst & Young LLP has served as our independent registered public accounting firm since 2010.

At the Annual Meeting, stockholders are being asked to ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2020. Stockholder ratification of the appointment of Ernst & Young LLP is not required by our bylaws or other applicable legal requirements. However, our board of directors is submitting the appointment of Ernst & Young LLP to our stockholders for ratification as a matter of good corporate governance. In the event that this appointment is not ratified by the affirmative vote of a majority of the shares present in person or by proxy at the Annual Meeting and entitled to vote, such appointment will be reconsidered by our audit committee. Even if the appointment is ratified, our audit committee, in its sole discretion, may appoint another independent registered public accounting firm at any time during our fiscal year ending December 31, 2020 if our audit committee believes that such a change would be in the best interests of Otonomy and its stockholders. If the appointment is not ratified by our stockholders, the Audit Committee may reconsider whether it should appoint another independent registered public accounting firm. A representative of Ernst & Young LLP is expected to be present at the Annual Meeting, will have an opportunity to make a statement if he or she wishes to do so, and is expected to be available to respond to appropriate questions from stockholders.

Fees Paid to the Independent Registered Public Accounting Firm

The following table presents fees for professional audit services and other services rendered to us by Ernst & Young LLP for our fiscal years ended December 31, 2019 and 2018.

   2019   2018 

Audit Fees (1)

  $528,000   $463,000 

Audit-Related Fees (2)

   90,000    —   

Tax Fees (3)

   86,000    64,000 

All Other Fees (4)

   2,000    6,000 
  

 

 

   

 

 

 
  $706,000   $533,000 
  

 

 

   

 

 

 

(1)

“Audit Fees” consist of fees billed for professional services rendered in connection with the audit of our annual financial statements, review of our quarterly financial statements, and services that are normally provided by Ernst & Young LLP in connection with statutory and regulatory filings or engagements for those fiscal years.

(2)

“Audit-Related Fees” consist of fees billed for professional services for assurance and related services that are reasonably related to the performance of the audit or review of our financial statements and are not reported under “Audit Fees.”

(3)

“Tax Fees” consist of fees billed for professional services rendered by Ernst & Young LLP for tax compliance, tax advice and tax planning.

(4)

“All Other Fees” consist of an annual license fee for an accounting database subscription.

Auditor Independence

In 2019, there were no other professional services provided by Ernst & Young LLP that would have required our audit committee to consider their compatibility with maintaining the independence of Ernst & Young LLP.

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Audit Committee Policy onPre-Approval of Audit and PermissibleNon-Audit Services of Independent Registered Public Accounting Firm

Our audit committee has established a policy governing our use of the services of our independent registered public accounting firm. Under the policy, our audit committee is required topre-approve all audit and permissiblenon-audit services performed by our independent registered public accounting firm in order to ensure that the provision of such services does not impair such accounting firm’s independence. All fees paid to Ernst & Young LLP for our fiscal years ended December 31, 2018 and 2019 werepre-approved by our audit committee.

Vote Required

The ratification of the appointment of Ernst & Young LLP requires the affirmative vote of a majority of the shares of our common stock present in person or by proxy at the Annual Meeting and entitled to vote thereon. Abstentions will have the effect of a vote AGAINST the proposal.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR OUR FISCAL YEAR ENDING DECEMBER 31, 2020.

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AUDIT COMMITTEE REPORT

The information contained in the following Audit Committee Report shall not be deemed to be soliciting material or to be filed with the Securities and Exchange Commission, nor shall such information be incorporated by reference into any future filing under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent that Otonomy, Inc., or the Company, specifically incorporates it by reference in such filing.

The audit committee serves as the representative of our board of directors with respect to its oversight of:2020:

 

our accounting and financial reporting processes and the audit of our financial statements;

the integrity of our financial statements;

our compliance with legal and regulatory requirements;

inquiring about significant risks, reviewing our policies for risk assessment and risk management, and assessing the steps management has taken to control these risks; and

the independent registered public accounting firm’s appointment, qualifications and independence.

The audit committee also reviews the performance of our independent registered public accounting firm, Ernst & Young LLP, in the annual audit of our financial statements and in assignments unrelated to the audit, and reviews the independent registered public accounting firm’s fees.

The audit committee is composed of threenon-employee directors. Our board of directors has determined that each member of the audit committee is independent, and that Ms. Capps qualifies as an “audit committee financial expert” under the SEC rules.

The audit committee provides our board of directors such information and materials as it may deem necessary to make our board of directors aware of financial matters requiring the attention of our board of directors. The audit committee reviews our financial disclosures and meets privately, outside the presence of our management, with our independent registered public accounting firm. In fulfilling its oversight responsibilities, the audit committee reviewed and discussed the audited financial statements in our 2019 Annual Report on Form10-K with management, including a discussion of the quality and substance of the accounting principles, the reasonableness of significant judgments made in connection with the audited financial statements, and the clarity of disclosures in the financial statements. The audit committee reports on these meetings to our board of directors.

The audit committee has reviewed and discussed the Company’s audited financial statements with management and Ernst & Young LLP, the Company’s independent registered public accounting firm. The audit committee has discussed with Ernst & Young LLP the matters required to be discussed by the applicable requirements of the Public Company Accounting Oversight Board (the “PCAOB”) and the Securities and Exchange Commission.

The audit committee has received and reviewed the written disclosures and the letter from Ernst & Young LLP required by the applicable requirements of the PCAOB regarding Ernst & Young LLP’s communications with the audit committee concerning independence and has discussed with Ernst & Young LLP its independence. In addition, the audit committee has discussed with Ernst & Young LLP its independence from management and the Company, including matters in the letter from Ernst & Young LLP required by PCAOB Rule 3526,Communication with Audit Committees Concerning Independence, and considered the compatibility ofnon-audit services with Ernst & Young LLP’s independence.

Based on the review and discussions referred to above, the audit committee recommended to our board of directors that the Company’s audited financial statements be included in the Company’s Annual Report on

-25-


Form 10-K for the fiscal year ended December 31, 2019 for filing with the Securities and Exchange Commission. The audit committee also has selected Ernst & Young LLP as the independent registered public accounting firm for fiscal year 2020. Our board of directors recommends that stockholders ratify this selection at the Annual Meeting.

Respectfully submitted by the members of the audit committee of the board of directors:

Vickie Capps (Chair)

James B. Breitmeyer, M.D., Ph.D.

 

 

Fees Earned

 

 

 

 

 

 

 

 

 

 

 

or Paid in

 

 

Option

 

 

 

 

 

Name

 

Cash ($)

 

 

Awards ($)(1)(2)

 

 

Total ($)

 

James Breitmeyer, M.D., Ph.D.

 

 

51,625

 

 

 

47,567

 

 

 

99,192

 

Vickie Capps

 

 

57,688

 

 

 

47,567

 

 

 

105,255

 

Ciara Kennedy, Ph.D. (3)

 

 

36,229

 

 

 

132,736

 

 

 

168,965

 

Jay Lichter, Ph.D.

 

 

71,625

 

 

 

47,567

 

 

 

119,192

 

Iain McGill

 

-26-

53,750


47,567

101,317

Heather Preston, M.D. (4)

6,458

6,458

Theodore R. Schroeder

49,500

47,567

97,067

EXECUTIVE OFFICERS(1)

This column reflects the aggregate grant date fair value of stock options granted during 2020 computed in accordance withthe provisions of Accounting Standards Codification (ASC) 718, Compensation—Stock Compensation. The following table sets forth certain information aboutassumptions that we used to calculate these amounts are discussed in Note 10 to our executive officers and their respective ages as of Marchaudited financial statements for the year ended December 31, 2020 included in our Annual Report on Form 10-K for the year ended December 31, 2020. These amounts do not reflect the actual economic value that will be realized by the director upon the vesting of the stock options, the exercise of the stock options, or the sale of the common stock underlying such stockoptions.

(2)

As of December 31, 2020, our non-employee directors held outstanding options to purchase the number of shares of common stock as follows: Dr. Breitmeyer (70,000 shares), Ms. Capps (97,500 shares); Dr. Kennedy (52,500 shares); Dr. Lichter (97,500 shares); Mr. McGill(92,500 shares); and Mr. Schroeder (107,500shares).

(3)

Dr. Kennedy joined as a member of our board of directors on March 1, 2020.

(4)

Dr. Preston served as a member of our board of directors until February 28, 2020.

See “Executive Compensation” for information about the compensation of directors who are also our employees.


PROPOSAL NO. 1

ELECTION OF DIRECTORS

Our board of directors is currently composed of seven (7) members. In accordance with our certificate of incorporation, our board of directors is divided into three classes with staggered three-year terms. At the Annual Meeting, two Class I directors will be elected for a three-year term to succeed the same class whose term is then expiring.

Each director’s term continues until the election and qualification of such director’s successor, or such director’s earlier death, resignation, or removal. Any increase or decrease in the number of directors will be distributed among the three classes so that, as nearly as possible, each class will consist of one-third of our directors. This classification of our board of directors may have the effect of delaying or preventing changes in control of our company.

Nominees

Our corporate governance and nominating committee has recommended, and our board of directors has approved James B. Breitmeyer, M.D., Ph.D. and David A. Weber, Ph.D. as nominees for election as Class I directors at the Annual Meeting. If elected, each of Drs. Breitmeyer and Weber will serve as Class I directors until the 2024 annual meeting of stockholders or until their successors are duly elected and qualified. Drs. Breitmeyer and Weber, are currently directors of our company, and each has agreed to being named in this proxy statement as nominees. For information concerning the nominees, please see “Board of Directors and Corporate Governance.”

If you are a stockholder of record and you sign your proxy card or vote over the Internet or by telephone but do not give instructions with respect to the voting of directors, your shares will be voted FOR the election of James B. Breitmeyer, M.D., Ph.D. and David A. Weber, Ph.D. We expect that Drs. Breitmeyer and Weber will accept such nomination; however, in the event that a director nominee is unable or declines to serve as a director at the time of the Annual Meeting, the proxies will be voted for any nominee who shall be designated by our board of directors to fill such vacancy. If you are a beneficial owner of shares of our common stock and you do not give voting instructions to your broker, bank or other nominee, then your broker, bank or other nominee will leave your shares unvoted on this matter.

Vote Required

The election of Class I directors requires a plurality vote of the shares of our common stock present in person (including virtually) or by proxy at the Annual Meeting and entitled to vote thereon to be approved. Broker non-votes will have no effect on this proposal.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE ELECTION OF EACH OF THE TWO DIRECTORS NOMINATED BY OUR BOARD OF DIRECTORS AND NAMED IN THIS PROXY STATEMENT AS CLASS I DIRECTORS TO SERVE FOR A THREE-YEAR TERM.


PROPOSAL NO. 2

ADVISORY VOTE ON THE COMPENSATION

OF OUR NAMED EXECUTIVE OFFICERS

In accordance with the Dodd-Frank Wall Street Reform and Consumer Protection Act of 2010 (the “Dodd-Frank Act”) and SEC rules, we are providing our stockholders with the opportunity to vote to approve, on an advisory or non-binding basis, the compensation paid to our named executive officers as disclosed in this proxy statement pursuant to Section 14A of the Exchange Act. This proposal, commonly known as a “Say-on-Pay” proposal, gives our stockholders the opportunity to express their views on our named executive officers’ compensation as a whole. This vote is not intended to address any specific item of compensation or any specific named executive officer, but rather the overall compensation of all of our named executive officers and the philosophy, policies and practices described in this proxy statement.

The Say-on-Pay vote is advisory, and therefore is not binding on us, our compensation committee, or our board of directors. The Say-on-Pay vote will, however, provide information to us regarding investor sentiment about our executive compensation philosophy, policies and practices, which our compensation committee will be able to consider when determining executive compensation for the remainder of the current fiscal year and beyond. Our board of directors and our compensation committee value the opinions of our stockholders. Accordingly, our board of directors and our compensation committee will consider the outcome of this vote when making future compensation decisions for our named executive officers.

We believe that the information provided in the section titled “Executive Compensation” demonstrates that our executive compensation program was designed appropriately and is working to ensure management’s interests are aligned with our stockholders’ interests to support long-term value creation. Accordingly, we ask our stockholders to vote “FOR” the following resolution at the Annual Meeting:

“RESOLVED, that the stockholders approve, on a non-binding advisory basis, the compensation paid to our named executive officers, as disclosed in the proxy statement for the Annual Meeting pursuant to the compensation disclosure rules of the SEC, including the compensation tables and narrative discussion and other related disclosure.”

Vote Required

The approval of, on a non-binding advisory basis, the compensation paid to our named executive officers, requires the affirmative vote of a majority of the voting power of the shares of our common stock present in person (including virtually) or by proxy at the Annual Meeting and entitled to vote thereon to be approved. Abstentions will have the effect of a vote against this proposal, and broker non-votes will have no effect.

As an advisory vote, the result of this proposal is non-binding. Although the vote is non-binding, our board of directors and our compensation committee value the opinions of our stockholders and will consider the outcome of the vote when making future compensation decisions for our named executive officers.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE APPROVAL OF, ON A NON-BINDING ADVISORY BASIS, THE COMPENSATION PAID TO OUR NAMED EXECUTIVE OFFICERS, AS DISCLOSED IN THIS PROXY STATEMENT.


PROPOSAL NO. 3

RATIFICATION OF APPOINTMENT OF

INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Our audit committee has appointed Ernst & Young LLP, as our independent registered public accounting firm to audit our financial statements for our fiscal year ending December 31, 2021. Ernst & Young LLP has served as our independent registered public accounting firm since 2010.

At the Annual Meeting, stockholders are being asked to ratify the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2021. Stockholder ratification of the appointment of Ernst & Young LLP is not required by our bylaws or other applicable legal requirements. However, our board of directors is submitting the appointment of Ernst & Young LLP to our stockholders for ratification as a matter of good corporate governance. In the event that this appointment is not ratified by the affirmative vote of a majority of the shares present in person (including virtually) or by proxy at the Annual Meeting and entitled to vote, such appointment will be reconsidered by our audit committee. Even if the appointment is ratified, our audit committee, in its sole discretion, may appoint another independent registered public accounting firm at any time during our fiscal year ending December 31, 2021 if our audit committee believes that such a change would be in the best interests of Otonomy and its stockholders. If the appointment is not ratified by our stockholders, the Audit Committee may reconsider whether it should appoint another independent registered public accounting firm. A representative of Ernst & Young LLP is expected to be present at the Annual Meeting, will have an opportunity to make a statement if he or she wishes to do so, and is expected to be available to respond to appropriate questions from stockholders.

Fees Paid to the Independent Registered Public Accounting Firm

The following table presents fees for professional audit services and other services rendered to us by Ernst & Young LLP for our fiscal years ended December 31, 2020 and 2019.

 

 

2020

 

 

2019

 

Audit Fees (1)

 

$

393,000

 

 

$

528,000

 

Audit-Related Fees (2)

 

 

222,000

 

 

 

90,000

 

Tax Fees (3)

 

 

75,000

 

 

 

86,000

 

All Other Fees (4)

 

 

 

 

 

2,000

 

 

 

$

690,000

 

 

$

706,000

 

(1)

“Audit Fees” consist of fees billed for professional services rendered in connection with the audit of our annual financial statements, review of our quarterly financial statements, and services that are normally provided by Ernst & Young LLP in connection withstatutory and regulatory filings or engagements for those fiscalyears.

(2)

“Audit-Related Fees” consist of fees billed for professional services for assurance and related services that are reasonably related to the performance of the audit or review of our financial statements and are not reported under “Audit Fees.”

(3)

“Tax Fees” consist of fees billed for professional services rendered by Ernst & Young LLP for tax compliance, tax advice andtax planning.

(4)

“All Other Fees” consist of an annual license fee for an accounting database subscription.

Auditor Independence

In 2020, there were no other professional services provided by Ernst & Young LLP that would have required our audit committee to consider their compatibility with maintaining the independence of Ernst & Young LLP.

Audit Committee Policy on Pre-Approval of Audit and Permissible Non-Audit Services of Independent Registered Public Accounting Firm

Our audit committee has established a policy governing our use of the services of our independent registered public accounting firm. Under the policy, our audit committee is required to pre-approve all audit and permissible non-audit services performed by our independent registered public accounting firm in order to ensure that the provision of such services does not impair such accounting firm’s independence. All fees paid to Ernst & Young LLP for our fiscal years ended December 31, 2019 and 2020 were pre-approved by our audit committee.

Vote Required

The ratification of the appointment of Ernst & Young LLP requires the affirmative vote of a majority of the shares of our common stock present in person (including virtually) or by proxy at the Annual Meeting and entitled to vote thereon. Abstentions will have the effect of a vote AGAINST the proposal.

THE BOARD OF DIRECTORS RECOMMENDS A VOTE “FOR” THE RATIFICATION OF THE APPOINTMENT OF ERNST & YOUNG LLP AS OUR INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM FOR OUR FISCAL YEAR ENDING DECEMBER 31, 2021.


AUDIT COMMITTEE REPORT

The information contained in the following Audit Committee Report shall not be deemed to be soliciting material or to be filed with the Securities and Exchange Commission, nor shall such information be incorporated by reference into any future filing under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, except to the extent that Otonomy, Inc., or the Company, specifically incorporates it by reference in such filing.

The audit committee serves as the representative of our board of directors with respect to its oversight of:

our accounting and financial reporting processes and the audit of our financialstatements;

the integrity of our financialstatements;

our compliance with legal and regulatoryrequirements;

inquiring about significant risks, reviewing our policies for risk assessment and risk management, and assessing the steps management has taken to control these risks;and

the independent registered public accounting firm’s appointment, qualifications andindependence.

The audit committee also reviews the performance of our independent registered public accounting firm, Ernst & Young LLP, in the annual audit of our financial statements and in assignments unrelated to the audit, and reviews the independent registered public accounting firm’s fees.

The audit committee is composed of three non-employee directors. Our board of directors has determined that each member of the audit committee is independent, and that Ms. Capps qualifies as an “audit committee financial expert” under the SEC rules.

The audit committee provides our board of directors such information and materials as it may deem necessary to make our board of directors aware of financial matters requiring the attention of our board of directors. The audit committee reviews our financial disclosures and meets privately, outside the presence of our management, with our independent registered public accounting firm. In fulfilling its oversight responsibilities, the audit committee reviewed and discussed the audited financial statements in our 2020 Annual Report on Form 10-K with management, including a discussion of the quality and substance of the accounting principles, the reasonableness of significant judgments made in connection with the audited financial statements, and the clarity of disclosures in the financial statements. The audit committee reports on these meetings to our board of directors.

The audit committee has reviewed and discussed the Company’s audited financial statements with management and Ernst & Young LLP, the Company’s independent registered public accounting firm. The audit committee has discussed with Ernst & Young LLP the matters required to be discussed by the applicable requirements of the Public Company Accounting Oversight Board (the “PCAOB”) and the Securities and Exchange Commission.

The audit committee has received and reviewed the written disclosures and the letter from Ernst & Young LLP required by the applicable requirements of the PCAOB regarding Ernst & Young LLP’s communications with the audit committee concerning independence and has discussed with Ernst & Young LLP its independence. In addition, the audit committee has discussed with Ernst & Young LLP its independence from management and the Company, including matters in the letter from Ernst & Young LLP required by PCAOB Rule 3526, Communication with Audit Committees Concerning Independence, and considered the compatibility of non-audit services with Ernst & Young LLP’s independence.

Based on the review and discussions referred to above, the audit committee recommended to our board of directors that the Company’s audited financial statements be included in the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2020 for filing with the Securities and Exchange Commission. The audit committee also has selected Ernst & Young LLP as the independent registered public accounting firm for fiscal year 2021. Our board of directors recommends that stockholders ratify this selection at the Annual Meeting.

Respectfully submitted by the members of the audit committee of the board of directors:

Vickie Capps (Chair)

James B. Breitmeyer, M.D., Ph.D.

Iain McGill


EXECUTIVE OFFICERS

The following table sets forth certain information about our executive officers and their respective ages as of March 31, 2021. Officers are elected by the board of directors to hold office until their successors are elected and qualified.

 

Name

Age

Age

Position

David A. Weber, Ph.D.

60President, Chief Executive Officer and Director

Paul E. Cayer

58Chief Financial and Business Officer

Robert Michael Savel, II

52Chief Technical Officer

For the biography of Dr. Weber, please see “Board of Directors and Corporate Governance—Continuing Directors.”

Paul E. Cayerhas served as our Chief Business Officer since October 2008, Chief Financial Officer since October 2010, and served as our Secretary from February 2011 until July 2015. Mr. Cayer brings more than 25 years of experience in the pharmaceutical, medical device and healthcare technology field. Prior to joining our company, Mr. Cayer served from 2005 to 2008 as Senior Vice President, Corporate Development for Verus Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the treatment of allergic and respiratory disorders in children. Mr. Cayer has also held various management positions with Targeted Molecules Corporation, a biopharmaceutical company, Gensia Pharmaceuticals, Inc., a biopharmaceutical company, Acuson, a provider of medical ultrasound systems, Castle & Cooke, a consumer products company, and served as consultant with Booz-Allen & Hamilton, a management and technology consulting firm. Mr. Cayer received his MBA and Bachelor’s degree in biomechanical engineering from Harvard University.

Robert Michael Savel, IIhas served as our Chief Technical Officer since January 2014. From September 2011 to December 2013, Mr. Savel served as General Manager and Senior Vice President of Operations for Optimer Pharmaceuticals, Inc., a biopharmaceutical company. From September 2010 to June 2011, Mr. Savel served as Senior Vice President and Chief Technical Officer for Inspire Pharmaceuticals, Inc., an ophthalmic pharmaceutical company. From April 2008 to September 2010, Mr. Savel served as President of Savel Enterprises LLC, a management consulting firm. From April 2007 to April 2008, Mr. Savel served as the Senior Vice President of Technical Operations for PDL BioPharma, a biotech company. Earlier in his career, he held leadership operating positions with Johnson & Johnson, a medical device, pharmaceutical and consumer packaged goods manufacturer, which included the position of Vice President, Quality and Compliance. Mr. Savel received his Bachelor’s degree in mechanical engineering from Virginia Polytechnic Institute and State University in Blacksburg, Virginia.

-27-


EXECUTIVE COMPENSATION

Processes and Procedures for Compensation Decisions

The following discussion of our processes and procedures for making compensation decisions for our named executive officers should be read together with the compensation tables and related disclosures set forth below. Our named executive officers for 2019, which consist of our principal executive officer and the next two most highly compensated executive officers, are:

David A. Weber, Ph.D.,

61

President, and Chief Executive Officer;Officer and Director

Paul E. Cayer

59

Chief Financial and Business Officer; andOfficer

Alan C. Foster, Ph.D.

 

65

Chief Scientific Officer

Robert MichaelM. Savel, II

53

Chief Technical Officer.Officer

Role of Compensation Committee

Our compensation committee is responsible for the executive compensation programs for our executive officers and reports to our Board of Directors on its discussions, decisions and other actions. The compensation committee approves the compensation of our named executive officers, and provides recommendations to our board of directors for our chief executive officer’s (“CEO”) compensation. As part of the decision-making process, the compensation committee considers our overall performance compared to our corporate objectives, reviews competitive market information with our CEO for each executive officer, as well as their performance against objectives, together with their respective scope of responsibilities and experience level.

Role of Compensation Committee Consultant

Our compensation committee is authorized to retain the services of one or more executive compensation advisors, as it sees fit, in connection with the establishment of our compensation programs and related policies. Our compensation committee retained Radford, a national compensation consultant, to provide it with information, recommendations and other advice relating to executive compensation on an ongoing basis. Accordingly, Radford now serves at the discretion of our compensation committee. Radford has implemented policies and procedures to ensure the objectivity of its executive compensation consultants and the advice it provides to the compensation committee. The compensation committee conducts an annual assessment of Radford’s independence pursuant to the SEC rules and NASDAQ listing standards and concluded that Radford’s work did not give rise to any conflict of interest.

The compensation committee engaged Radford to conduct a competitive analysis of our executive compensation program. In connection with this analysis, Radford analyzed both publicly available data from the companies in our compensation peer group and compensation survey data, while also reviewing and considering historical data insights into our compensation practice and programs, with a goal of ensuring that the compensation we offer to our executive officers is competitive and fair.

Role of Management

Management provides data, analysis, input and recommendations to the compensation committee through our CEO regarding short- and long-term compensation for all executive officers (other than himself) based on our results, an individual executive officer’s contribution toward these results and performance toward goal achievement. Our compensation committee then reviews the Radford and management recommendations and other data and makes decisions as to total compensation for each executive officer other than the CEO, as well as each individual compensation component. While the compensation committee gives reasonable weight to our CEO’s evaluation of each executive officer’s performance and recommendation of appropriate compensation, the Compensation Committee’s decisions are made by the compensation committee in its sole discretion, and outside of the presence of any effected executive officers. As noted above, our compensation committee approves and

-28-


makes recommendations to our Board of Directors for approval the compensation for the CEO. The independent members of our board of directors make the final decisions regarding executive compensation for the CEO.

Use of Peer Group Data

Annually our compensation committee evaluates the peer group for suitability and modifies the peer group as needed. Our compensation committee engaged Radford to assist in developing an appropriate group of peer companies, with consideration of sector, business stage/revenue, and market capitalization, among other factors to complete a competitive analysis of the components of our executive compensation program and to help us determine the appropriate level of overall compensation for our executive officers. The compensation committee uses the peer group data as one factor in determining the appropriate levels of overall total compensation and each individual compensation element for our executive officers. In addition to peer group data, as noted above, the compensation committee also considers market information and other data and analytics provided by Radford and management.

For the biography of Dr. Weber, please see “Board of Directors and Corporate Governance—Continuing Directors.”

Paul E. Cayer has served as our Chief Business Officer since October 2008, Chief Financial Officer since October 2010, and served as our Secretary from February 2011 until July 2015 and again beginning in February 2021. Mr. Cayer brings more than 30 years of experience in the pharmaceutical, medical device and healthcare technology field. Prior to joining our company, Mr. Cayer served from 2005 to 2008 as Senior Vice President, Corporate Development for Verus Pharmaceuticals, Inc., a specialty pharmaceutical company focused on the treatment of allergic and respiratory disorders in children. Mr. Cayer has also held various management positions with Targeted Molecules Corporation, a biopharmaceutical company, Gensia Pharmaceuticals, Inc., a biopharmaceutical company, Acuson, a provider of medical ultrasound systems, Castle & Cooke, a consumer products company, and served as consultant with Booz-Allen & Hamilton, a management and technology consulting firm. Mr. Cayer received his Bachelor’s degree in biomechanical engineering from HarvardUniversity and MBA from the Harvard Business School.

Alan C. Foster, Ph.D. was promoted to Chief Scientific Officer in April 2021, prior to which he served as our Vice President, Research since December 2014. Dr. Foster is a neuroscientist and pharmacologist with over 35 years of drug discovery and development experience. During his career, he has led research programs that identified multiple drug candidates for a wide range of biological targets in the neuroscience, ophthalmology and neurotology therapeutic areas. Prior to Otonomy, he served as Vice President of Pharmacology at Allergan, Inc., and Vice President of Neuroscience at Neurocrine Biosciences, Inc. Previously, he held research leadership positions at Gensia, Inc. and Merck. Dr. Foster was a post-doctoral fellow at both the University of California, Irvine, Department of Psychobiology, and the Maryland Psychiatric Research Center, University of Maryland School of Medicine. He obtained his Ph.D. in Neuropharmacology and a Bachelor’s degree in Physiology and Biochemistry from the University of Southampton, United Kingdom.

Robert M. Savel, II has served as our Chief Technical Officer since January 2014. From September 2011 to December 2013, Mr. Savel served as General Manager and Senior Vice President of Operations for Optimer Pharmaceuticals, Inc., a biopharmaceutical company. From September 2010 to June 2011, Mr. Savel served as Senior Vice President and Chief Technical Officer for Inspire Pharmaceuticals, Inc., an ophthalmic pharmaceutical company. From April 2008 to September 2010, Mr. Savel served as President of Savel Enterprises LLC, a management consulting firm providing technical and operational support to biopharmaceutical clients. From April 2007 to April 2008, Mr. Savel served as the Senior Vice President of Technical Operations for PDL BioPharma. Earlier in his career, he held leadership operating positions with Johnson & Johnson, which included the position of Vice President, Quality and Compliance. Mr. Savel received his Bachelor’s degree in mechanical engineering from Virginia Polytechnic Institute and State University in Blacksburg,Virginia.


EXECUTIVE COMPENSATION

Overview

The Company is a “smaller reporting company” under Item 10 of Regulation S-K promulgated under the Exchange Act, and the following compensation disclosure is intended to comply with the requirements applicable to smaller reporting companies. Although the rules allow us to provide less detail about our executive compensation program, our compensation committee is committed to providing the information necessary to help stockholders understand our executive compensation-related decisions. Accordingly, this section includes supplemental narratives that describe the 2020 executive compensation program for our named executive officers.

The following discussion of our processes and procedures for making compensation decisions for our named executive officers should be read together with the compensation tables and related disclosures set forth below. Our named executive officers for 2020, which consist of our principal executive officer and the next two most highly compensated executive officers, are:

David A. Weber, Ph.D., President and Chief ExecutiveOfficer;

Paul E. Cayer, Chief Financial and Business Officer;and

Robert M. Savel, II, Chief TechnicalOfficer.

Compensation Philosophy

Our compensation programs are designed to:

Support corporate objectives intended to drive stockholder value and promote the long-term growth of the Company.

Attract, incentivize and retain superior talent at the executive level through competitive compensation programs/arrangements.

Align rewards to the achievement of corporate goals intended to drive stockholder value.

Base executive rewards on achievement of measurable corporate goals that align to our strategic priorities and tactics to build stockholder value, as well as using equity awards to further align the interest of executives and stockholders.

Role of Compensation Committee

Our compensation committee is responsible for the executive compensation programs for our executive officers and reports to our board of directors on its discussions, decisions and other actions.  The compensation committee approves the compensation of our named executive officers, and provides recommendations to our board of directors for our CEO’s compensation. As part of the decision-making process, the compensation committee considers our overall performance compared to our corporate objectives, reviews competitive market information with our CEO for each executive officer, as well as their performance against objectives, together with their respective scope of responsibilities and experience level.

Role of Compensation Committee Consultant

Our compensation committee is authorized to retain the services of one or more executive compensation advisors, as it sees fit, in connection with the establishment of our compensation programs and related policies. Our compensation committee retained Radford, part of the Rewards Solutions practice at Aon plc. (“Radford”), a national compensation consultant, to provide it with information, recommendations and other advice relating to executive compensation on an ongoing basis.  Accordingly, Radford now serves at the discretion of our compensation committee. Radford has implemented policies and procedures to ensure the objectivity of its executive compensation consultants and the advice it provides to the compensation committee. The compensation committee conducts an annual assessment of Radford’s independence pursuant to the SEC rules and NASDAQ listing standards and concluded that Radford’s work did not give rise to any conflict of interest.

The compensation committee engaged Radford to conduct a competitive analysis of our executive compensation program. In connection with this analysis, Radford analyzed both publicly available data from the companies in our compensation peer group and compensation survey data, while also reviewing and considering historical data insights into our compensation practice and programs, with a goal of ensuring that the compensation we offer to our executive officers is competitive and fair.


Role of Management

Management provides data, analysis, input and recommendations to the compensation committee through our CEO regarding short- and long-term compensation for all executive officers (other than himself) based on our results, an individual executive officer’s contribution toward these results and performance toward goal achievement. Our compensation committee then reviews the Radford and management recommendations and other data and makes decisions as to total compensation for each executive officer other than the CEO, as well as each individual compensation component. While the compensation committee gives reasonable weight to our CEO’s evaluation of each executive officer’s performance and recommendation of appropriate compensation, the Compensation Committee’s decisions are made by the compensation committee in its sole discretion, and outside of the presence of any affected executive officers.  As noted above, our compensation committee approves and makes recommendations to our Board of Directors for approval the compensation for the CEO. The independent members of our board of directors make the final decisions regarding executive compensation for the CEO.

Use of Peer Group Data

Annually our compensation committee evaluates the peer group for suitability and modifies the peer group as needed.  Our compensation committee engaged Radford to assist in developing an appropriate group of peer companies, with consideration of sector, business stage/revenue, and market capitalization, among other factors to complete a competitive analysis of the components of our executive compensation program and to help us determine the appropriate level of overall compensation for our executive officers.  The compensation committee uses the peer group data as one factor in determining the appropriate levels of overall total compensation and each individual compensation element for our executive officers. In addition to peer group data, as noted above, the compensation committee also considers market information and other data and analytics provided by Radford and management.

Summary Compensation Table

The following table provides information regarding the compensation of our named executive officers during the years ended December 31, 2020 and 2019.

 

 

 

 

 

 

 

 

 

 

 

 

Option

 

 

All Other

 

 

 

 

 

Name and Principal Position

 

Year

 

Salary ($)

 

 

Bonus ($)(1)

 

 

Awards

($)(2)

 

 

Compensation

($)(3)

 

 

Total ($)

 

David A. Weber, Ph.D.

 

2020

 

 

567,736

 

 

 

357,674

 

 

 

1,925,910

 

 

 

1,680

 

 

 

2,853,000

 

President and Chief Executive Officer

 

2019

 

 

545,900

 

 

 

327,540

 

 

 

1,278,000

 

 

 

1,680

 

 

 

2,153,120

 

Paul E. Cayer

 

2020

 

 

410,000

 

 

 

172,200

 

 

 

1,348,137

 

 

 

1,260

 

 

 

1,931,597

 

Chief Financial and Business Officer

 

2019

 

 

395,185

 

 

 

158,074

 

 

 

359,438

 

 

 

1,260

 

 

 

913,957

 

Robert M. Savel, II

 

2020

 

 

366,000

 

 

 

153,720

 

 

 

687,825

 

 

 

1,610

 

 

 

1,209,155

 

Chief Technical Officer

 

2019

 

 

355,000

 

 

 

142,000

 

 

 

319,500

 

 

 

1,260

 

 

 

817,760

 

(1)

This column reflects bonus payments earned in 2020 and2019 and paid in the subsequent year.

(2)

This column reflects the aggregate grant date fair value of stock options granted during 2020 and 2019 computed in accordance withthe provisions of Accounting Standards Codification (“ASC”) 718, Compensation—Stock Compensation. The assumptions that we used to calculate these amounts are discussed in Note 10 to our audited financial statements for the year ended December 31, 2018 and 2019.

Name and Principal Position

 Year  Salary ($)  Bonus ($)(1)  Option
Awards ($)(2)
  All Other
Compensation
($)(3)
  Total ($) 

David A. Weber, Ph.D

  2019   545,900   327,540   1,278,000   1,680   2,153,120 

President and Chief Executive Officer

  2018   545,900   327,540   4,537,905   1,500   5,412,845 

Paul E. Cayer

  2019   395,185   158,074   359,438   1,260   913,957 

Chief Financial and Business Officer

  2018   395,185   158,074   1,164,013   1,500   1,718,772 

Robert Michael Savel, II

  2019   355,000   142,000   319,500   1,260   817,760 

Chief Technical Officer

  2018   355,000   142,000   1,136,387   1,500   1,634,887 

(1)

This column reflects bonus payments earned in 2018 and 2019 and paid in the subsequent year.2020 included in our Annual Report on Form 10-K for the year ended December 31, 2020. These amounts do not reflect the actual economic value that will be realized by the named executive officer upon the vesting of the stock options, the exercise of the stock options, or the sale of the common stock underlying such stockoptions.

(2)

This column reflects the aggregate grant date fair value of stock options granted during 2018 and 2019 computed in accordance with the provisions of Accounting Standards Codification (ASC) 718, Compensation—Stock Compensation. The assumptions that we used to calculate these amounts are discussed in Note 11 to our audited financial statements for the year ended December 31, 2019 included in our Annual Report on Form10-K

(3)

This column reflects the dollar value of the benefit to the named executive officer for the portion of the premium payable by us with respect to a life insurance policy. for the year ended December 31, 2019. These amounts do not reflect the actual economic value that will be realized by the named executive officer upon the vesting of the stock options, the exercise of the stock options, or the sale of the common stock underlying such stock options.

(3)

This column reflects the dollar value of the benefit to the named executive officer for the portion of the premium payable by the Company with respect to a life insurance policy.

-29-


Outstanding Equity Awards at FiscalOutstanding Equity Awards at Fiscal Year-End 2020 2019

The following table provides information regarding equity awards held by our named executive officers as of December 31, 2020.

Name

 

Commencement

 

Options

 

 

Exercise

 

 

Expiration

 

 

Date

 

Exercisable

 

 

Unexercisable

 

 

Price

 

 

Date

David A. Weber, Ph.D.

 

5/18/2011

 

57,414(1)

 

 

 

 

 

$

3.17

 

 

6/15/2021

 

 

9/1/2013

 

390,149(1)

 

 

 

 

 

$

1.76

 

 

12/20/2023

 

 

4/23/2014

 

242,747(1)

 

 

 

 

 

$

6.33

 

 

6/3/2024

 

 

1/19/2018

 

368,836(2)

 

 

4,496(2)

 

 

$

5.68

 

 

1/19/2026

 

 

2/1/2018

 

250,000(3)

 

 

 

 

 

$

5.80

 

 

2/1/2028

 

 

2/1/2018

 

283,333(4)

 

 

116,667(4)

 

 

$

5.80

 

 

2/1/2028

 

 

1/15/2019

 

383,333(4)

 

 

416,667(4)

 

 

$

2.02

 

 

1/15/2029

 

 

1/15/2020

 

 

 

 

700,000(4)

 

 

$

3.54

 

 

1/15/2030

Paul E. Cayer

 

9/18/2012

 

19,908(1)

 

 

 

 

 

$

1.06

 

 

9/18/2022

 

 

9/1/2013

 

137,088(1)

 

 

 

 

 

$

1.76

 

 

12/20/2023

 

 

4/23/2014

 

77,492(1)

 

 

 

 

 

$

6.33

 

 

6/3/2024

 

 

1/19/2018

 

131,810(5)

 

 

1,522(5)

 

 

$

5.68

 

 

1/19/2026

 

 

2/1/2018

 

92,083(4)

 

 

37,917(4)

 

 

$

5.80

 

 

2/1/2028

 

 

1/15/2019

 

107,812(4)

 

 

117,188(4)

 

 

$

2.02

 

 

1/15/2029

 

 

1/15/2020

 

 

 

 

490,000(4)

 

 

$

3.54

 

 

1/15/2030

Robert M. Savel, II

 

1/6/2014

 

79,047(1)

 

 

 

 

 

$

1.76

 

 

1/31/2024

 

 

4/23/2014

 

32,994(1)

 

 

 

 

 

$

6.33

 

 

6/3/2024

 

 

1/19/2018

 

88,898(6)

 

 

1,101(6)

 

 

$

5.68

 

 

1/19/2026

 

 

2/1/2018

 

116,875(4)

 

 

48,125(4)

 

 

$

5.80

 

 

2/1/2028

 

 

1/15/2019

 

95,833(4)

 

 

104,167(4)

 

 

$

2.02

 

 

1/15/2029

 

 

1/15/2020

 

 

 

 

250,000(4)

 

 

$

3.54

 

 

1/15/2030

(1)

All of the shares underlying the option were fully vested as of December 31, 2019.

   Option Awards 
   Vesting
Commencement
Date
   Number of Securities
Underlying Unexercised
Options
  Option
Exercise
Price
   Option
Expiration
Date
 

Name

  Exercisable  Unexercisable 

David A. Weber, Ph.D.

   11/21/2010    95,420(1)   —    $3.17    11/21/2020 
   5/18/2011    57,414(1)   —    $3.17    6/15/2021 
   9/1/2013    390,149(1)   —    $1.76    12/20/2023 
   4/23/2014    242,747(1)   —    $6.33    6/3/2024 
   1/19/2018    314,889(2)   58,433(2)  $5.68    1/19/2026 
   2/1/2018    250,000(3)   —    $5.80    2/1/2028 
   2/1/2018    183,333(4)   216,667(4)  $5.80    2/1/2028 
   1/15/2019    —     800,000(4)  $2.02    1/15/2029 

Paul E. Cayer

   6/16/2010    8,532(1)   —    $2.82    6/16/2020 
   11/19/2010    29,863(1)   —    $3.17    11/19/2020 
   9/18/2012    19,908(1)   —    $1.06    9/18/2022 
   9/1/2013    137,088(1)   —    $1.76    12/20/2023 
   4/23/2014    77,492(1)   —    $6.33    6/3/2024 
   1/19/2018    113,570(5)   19,762(5)  $5.68    1/19/2026 
   2/1/2018    59,583(4)   70,417(4)  $5.80    2/1/2028 
   1/15/2019    —     225,000(4)  $2.02    1/15/2029 

Robert Michael Savel, II

   1/6/2014    79,047(1)   —    $1.76    1/31/2024 
   4/23/2014    32,994(1)   —    $6.33    6/3/2024 
   1/19/2018    75,703(6)   14,296(6)  $5.68    1/19/2026 
   2/1/2018    75,625(4)   89,375(4)  $5.80    2/1/2028 
   1/15/2019    —     200,000(4)  $2.02    1/15/2029 

(1)

All of the shares underlying the option were fully vested as of December 31, 2019.2020.

(2)

Of the 373,332 shares subject to the option, 211,526 shares vested on January 19, 2019. Of the remaining 161,806 shares subject to the option, 211,526 shares vested on January 19, 2019. Of the remaining 161,806 shares subject to the option,one-third of these shares vested on January 19, 2019, and 1/36th of these shares vest monthly thereafter, subject to continued service through each vestingdate. of these shares vested on January 19, 2019, and 1/36th of these shares vest monthly thereafter, subject to continued service through each vesting date.

(3)

100% of the shares subject to the option vested in full on December 21, 2018 upon the Company’s satisfaction of certain performance criteria for the year ended December 31,

(3)

100% of the shares subject to the option vested in full on December 21, 2018 upon the Company’s satisfaction of certainperformance criteria for the year ended December 31,2018.

(4)

1/4th of the shares subject to the option vested on the first anniversary of the grant date and 1/48th of the shares subject to the option vest monthly thereafter, subject to continued service through each vesting date

(5)

Of the 133,332 shares subject to the option, 78,610 shares vested on January 19, 2019. Of the remaining 54,722 shares subject tothe option, 78,610 shares vested on January 19, 2019. Of the remaining 54,722 shares subject to the option,one-third of these shares vested on January 19, 2019 and 1/36th of these shares vest monthly thereafter, subject tocontinued service through each vestingdate. of these shares vested on January 19, 2019 and 1/36th of these shares vest monthly thereafter, subject to continued service through each vesting date.

(6)

Of the 89,999 shares subject to the option, 50,416 shares vested on January 19, 2019. Of the remaining 39,583 shares subject to the option,one-third of these shares vested on January 19, 2019, and 1/36th of these shares vest monthly thereafter, subject to continued service through each vesting date.

Non-Equity Incentive Plan Awards

Our named executive officers participated in a bonus program in 2019 under our Executive Incentive Compensation Plan (the “Bonus Plan”). The Bonus Plan allows our compensation committee (or board of directors with respect to our CEO) to provide cash incentive awards through the payment of bonuses to selected employees, including our named executive officers, determined by our compensation committee (or board of directors with respect to our CEO), based upon performance goals or other criteria established by our compensation committee (or board of directors with respect to our CEO). For 2019, bonuses awarded were based upon the achievement of performance metrics tied to the company’s corporate objectives, including pertaining to

-30-


option, 50,416 shares vested on January 19, 2019. Of the company’s advancement of its preclinical and clinical programs, and achievement of corporate development, operational and financial initiatives, as determined by the compensation committee and, with respectremaining 39,583 shares subject to the CEO, as determined by the boardoption, one-third of directors.

Executive Employment Agreements

David A. Weber, Ph.D.

We have entered into an employment agreement with Dr. Weber, effective asthese shares vested on January 19, 2019, and 1/36th of August 13, 2014. The employment agreement has an initial term of 4 years,these shares vest monthly thereafter, subject to earlier termination as provided in the employment agreement. Unless either party gives at least 90 days’ notice prior to the expiration of the initial term or the then-current additional term, as applicable, the employment agreement shall be renewed for an additional term of 1 year, incontinued service through each case, commencing on the expiration of the initial term or the then-current additional term, as the case may be, subject to earlier termination as provided in the employment agreement. In the event of a “change of control” (as defined in the employment agreement), if there is less than 12 months remaining in the initial term or then-current additional term, as applicable, the term will automatically extend until the12-monthvesting anniversary following the change of control. Pursuant to the agreement, Dr. Weber will continue to serve as our President and Chief Executive Officer on an “at will” basis. Dr. Weber’s base salary was $545,900 during 2018 and remained unchanged for 2019.date.

Equity Incentive Plan Awards

Equity compensation represents the largest at-risk element of our executive compensation program. Our equity compensation is designed to align the interests of our executive officers with those of our stockholders by creating an incentive for our executive officers to maximize stockholder value and to remain employed with us despite a competitive labor market. During the fiscal year ended December 31, 2020, we granted options to each of our named executive officers.

Equity opportunities are generally reviewed and determined annually at the beginning of the year or as appropriate during the year for new hires, promotions, or other special circumstances, such as to encourage retention. Individual grants are determined based on a number of factors, including current corporate and individual performance, outstanding equity holdings and their retention value and total ownership. This review also considers the retentive value of stock options, taking into account the stage of our clinical trials as well the proportion of options held by our CEO and leadership team that were underwater at the time awards were granted in 2020. Other factors we consider include historical value of our stock, internal equity amongst executives and market data provided by our independent compensation consultant.


Non-Equity Incentive Plan Awards

Our named executive officers participated in a bonus program in 2020 under our Executive Incentive Compensation Plan (the “Bonus Plan”).  The Bonus Plan allows our compensation committee (or board of directors with respect to our CEO) to provide cash incentive awards through the payment of bonuses to selected employees, including our named executive officers, determined by our compensation committee (or board of directors with respect to our CEO), based upon performance goals or other criteria established by our compensation committee (or board of directors with respect to our CEO).

For fiscal year 2020, the target annual bonuses for Dr. Weber and Messrs. Cayer and Savel were equal to 60%, 40% and 40%, respectively, of each NEO’s base salary.

Our corporate bonus objectives were based on operational and developmental milestones related to our clinical and preclinical development programs and business and corporate development initiatives.  We met key strategic milestones to advance our product pipeline and achieve our corporate objectives, while navigating the setbacks of a global pandemic. We completed enrollment in three clinical trials, and received positive clinical results for both OTO-313 in tinnitus and OTO-413 in hearing loss positioning the Company to continue clinical development in 2021 for both of these programs. We also further advanced development of our robust preclinical pipeline in neurotology by selecting a product candidate, OTO-825, for our GJB2 gene therapy program, demonstrating preclinical proof-of-concept for our OTO-510 otoprotection program, and licensing a novel compound for our OTO-6XX hair cell repair and regeneration program. Among additional key objectives met, we completed a public offering for total gross proceeds of $69.1 million to support our programs.

For 2020, bonuses awarded were based upon the 105% achievement of performance metrics tied to our corporate objectives, including pertaining to our advancement of our preclinical and clinical programs, and achievement of corporate development, operational and financial initiatives, as determined by the compensation committee and, with respect to the CEO, as determined by the board of directors.

Executive Employment Agreements

David A. Weber, Ph.D.

We have entered into an employment agreement with Dr. Weber, effective as of August 13, 2014. The employment agreement has an initial term of 4 years, subject to earlier termination as provided in the employment agreement. Unless either party gives at least 90 days’ notice prior to the expiration of the initial term or the then-current additional term, as applicable, the employment agreement shall be renewed for an additional term of 1 year, in each case, commencing on the expiration of the initial term or the then-current additional term, as the case may be, subject to earlier termination as provided in the employment agreement. In the event of a “change of control” (as defined in the employment agreement), if there is less than 12 months remaining in the initial term or then-current additional term, as applicable, the term will automatically extend until the 12-month anniversary following the change of control. Pursuant to the agreement, Dr. Weber will continue to serve as our President and Chief Executive Officer on an “at will” basis. Dr. Weber’s base salary was $545,900 during 2019 and was increased to $567,736 for 2020. He is eligible to receive an annual performance bonus with the target amount determined as 60% of his annual base salary and eligible to participate in employee benefit or group insurance plans maintained from time to time by us. Dr. Weber’s employment agreement also provides that he will continue to serve as a member of our board of directors during the term of his employment subject to board and/ or stockholder approval.

Pursuant to the employment agreement of Dr. Weber, if we terminate the employment of Dr. Weber other than for death, disability, or “cause” or Dr. Weber resigns for “good reason” (as such terms are defined in Dr. Weber’s employment agreement), and, within 60 days following his termination, Dr. Weber executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Dr. Weber is entitled to receive (i) continuing payments of his then-current base salary for a period of 12 months, payable pursuant to our regular payroll procedures, (ii) an amount equal to a pro rata portion of his target annual bonus for the year of termination, payable in accordance with our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for him and his respective dependents for up to 12 months, and (iv) additional vesting and exercisability as to any outstanding equity awards held by him as if he had remained our employee for an additional 24 months.

Pursuant to the employment agreement of Dr. Weber, if, within the 3 month period prior to or the 12 month period following a “change of control” (as defined in Dr. Weber’s employment agreement), the employment of Dr. Weber is terminated under the circumstances described in the above paragraph and, within 60 days following his termination, Dr. Weber executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Dr. Weber is entitled to receive (i) a lump sum payment equal to 18 months of his then-current base salary, payable pursuant to our regular payroll procedures, (ii) a lump sum payment equal to 150% of the higher of (x) his full target annual bonus for the fiscal year of termination, or (y) his full target annual bonus for the fiscal year in which the change of control occurs, payable pursuant to our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for him and his respective dependents for up to 18 months, and (iv) vesting acceleration of 100% with respect to any outstanding equity awards held by him on the date of his termination.


In the event any payment to Dr. Weber pursuant to his employment agreement would be subject to the excise tax imposed by Section 4999 of the Internal Revenue Code, as amended (the “Code”) (as a result of a payment being classified as a parachute payment under Section 280G of the Code), Dr. Weber will receive such payment as would entitle him to receive the greatest after-tax benefit, even if it means that we pay him a lower aggregate payment so as to minimize or eliminate the potential excise tax imposed by Section 4999 of the Code.

Paul E. Cayer

We have entered into an employment agreement with Mr. Cayer, effective as of August 13, 2014. The employment agreement has an initial term of 4 years, subject to earlier termination as provided in the employment agreement. Unless either party gives at least 90 days’ notice prior to the expiration of the initial term or the then-current additional term, as applicable, the employment agreement shall be renewed for an additional term of 1 year, in each case, commencing on the expiration of the initial term or the then-current additional term, as the case may be, subject to earlier termination as provided in the employment agreement. In the event of a “change of control” (as defined in the employment agreement), if there is less than 12 months remaining in the initial term or then-current additional term, as applicable, the term will automatically extend until the 12-month anniversary following the change of control. Pursuant to the agreement, Mr. Cayer will continue to serve as our Chief Financial and Business Officer on an “at will” basis. Mr. Cayer’s base salary was $395,185 during 2019 and was increased to $410,000 for 2020. He is eligible to receive an annual performance bonus with the target amount determined as 40% of his annual base salary and eligible to participate in employee benefit or group insurance plans maintained from time to time by us.

Pursuant to the employment agreement of Mr. Cayer, if we terminate the employment of Mr. Cayer other than for death, disability, or “cause” or Mr. Cayer resigns for “good reason” (as such terms are defined in Mr. Cayer’s employment agreement), and, within 60 days following his termination, Mr. Cayer executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director,  Mr. Cayer is entitled to receive (i) continuing payments of his then-current base salary for a period of 9 months, payable pursuant to our regular payroll procedures, (ii) an amount equal to a pro rata portion of his target annual bonus for the year of termination, payable in accordance with our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for him and his respective dependents for up to 9 months, and (iv) additional vesting and exercisability as to any outstanding equity awards held by him as if he had remained our employee for an additional 12 months.

Pursuant to the employment agreement of Mr. Cayer, if, within the 3 month period prior to or the 12 month period following a “change of control” (as defined in Mr. Cayer’s employment agreement), the employment of Mr. Cayer is terminated under the circumstances described in the above paragraph and, within 60 days following his termination, Mr. Cayer executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Mr. Cayer is entitled to receive (i) a lump sum payment equal to 12 months of his then-current base salary, payable pursuant to our regular payroll procedures, (ii) a lump sum payment equal to the higher of (x) his full target annual bonus for the fiscal year of termination, or (y) his full target annual bonus for the fiscal year in which the change of control occurs, payable pursuant to our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for him and his respective dependents for up to 12 months, and (iv) vesting acceleration of 100% with respect to any outstanding equity awards held by him on the date of his termination.

In the event any payment to Mr. Cayer pursuant to his employment agreement would be subject to the excise tax imposed by Section 4999 of the Code (as a result of a payment being classified as a parachute payment under Section 280G of the Code), Mr. Cayer will receive such payment as would entitle him to receive the greatest after-tax benefit, even if it means that we pay him a lower aggregate payment so as to minimize or eliminate the potential excise tax imposed by Section 4999 of the Code.

Robert M. Savel, II

We have entered into an employment agreement with Mr. Savel, effective as of July 31, 2014. The employment agreement has an initial term of 4 years, subject to earlier termination as provided in the employment agreement. Unless either party gives at least 90 days’ notice prior to the expiration of the initial term or the then-current additional term, as applicable, the employment agreement shall be renewed for an additional term of 1 year, in each case, commencing on the expiration of the initial term or the then-current additional term, as the case may be, subject to earlier termination as provided in the employment agreement. In the event of a “change of control” (as defined in the employment agreement), if there is less than 12 months remaining in the initial term or then-current additional term, as applicable, the term will automatically extend until the 12-month anniversary following the change of control. Pursuant to the agreement, Mr. Savel will continue to serve as our Chief Technology Officer on an “at will” basis. Mr. Savel’s base salary was $355,000 during 2019 and was increased to $366,000 for 2020. He is eligible to receive an annual performance bonus with the target amount determined as 40% of his annual base salary and eligible to participate in employee benefit or group insurance plans maintained from time to time by us.


Pursuant to the employment agreement of Mr. Savel, if we terminate the employment of Mr. Savel other than for death, disability, or “cause” or Mr. Savel resigns for “good reason” (as such terms are defined in Mr. Savel’s employment agreement), and, within 60 days following his termination, Mr. Savel executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Mr. Savel is entitled to receive (i) continuing payments of his then-current base salary for a period of 9 months, payable pursuant to our regular payroll procedures, (ii) an amount equal to a pro rata portion of his target annual bonus for the year of termination, payable in accordance with our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for his and his respective dependents for up to 9 months, and (iv) additional vesting and exercisability as to any outstanding equity awards held by him as if he had remained our employee for an additional 12 months.

Pursuant to the employment agreement of Mr. Savel, if, within the 3 month period prior to or the 12 month period following a “change of control” (as defined in Mr. Savel’s employment agreement), the employment of Mr. Savel is terminated under the circumstances described in the above paragraph and, within 60 days following his termination, Mr. Savel executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Mr. Savel is entitled to receive (i) a lump sum payment equal to 12 months of his then-current base salary, payable pursuant to our regular payroll procedures, (ii) a lump sum payment equal to the higher of (x) his full target annual bonus for the fiscal year of termination, or (y) his full target annual bonus for the fiscal year in which the change of control occurs, payable pursuant to our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for his and his respective dependents for up to 12 months, and (iv) vesting acceleration of 100% with respect to any outstanding equity awards held by him on the date of his termination.

In the event any payment to Mr. Savel pursuant to his employment agreement would be subject to the excise tax imposed by Section 4999 of the Code (as a result of a payment being classified as a parachute payment under Section 280G of the Code), Mr. Savel will receive such payment as would entitle him to receive the greatest after-tax benefit, even if it means that we pay him a lower aggregate payment so as to minimize or eliminate the potential excise tax imposed by Section 4999 of the Code.

Equity Compensation Plan Information

The following table provides information as of December 31, 2020 with respect to shares of our common stock that may be issued under our existing equity compensation plans.

Plan Category

 

Number of

Securities to be

Issued upon

Exercise of

Outstanding

Options,

Restricted

Stock Units

and Rights

 

 

Weighted Average

Exercise Price of

Outstanding Options

and Rights

 

 

Number of Securities

Remaining Available

for Future Issuance

Under Equity

Compensation Plans

(Excluding Securities

Reflected in the first

Column)

 

Equity compensation plans approved by security holders

 

 

 

 

 

 

 

 

 

 

 

 

2010 Equity Incentive Plan (1)

 

1,297,478(4)

 

 

$

3.48

 

 

 

 

2014 Equity Incentive Plan (2)

 

8,545,266(5)

 

 

$

4.20

 

 

 

2,553,854

 

2014 Employee Stock Purchase Plan (3)

 

 

 

 

 

 

 

 

2,301,704

 

Equity compensation plans not approved by security holders

 

 

 

 

 

 

 

 

 

TOTAL

 

 

9,842,744

 

 

$

4.11

 

 

 

4,855,558

 

(1)

Our board of directors adopted, and our stockholders approved, the 2010 Equity Incentive Plan, as amended (“2010 Plan”). As a resultof our initial public offering and the adoption of the 2014 Equity Incentive Plan (“2014 Plan”), we no longer grant awards under the 2010 Plan; however, all outstanding options issued pursuant to the 2010 Plan continue to be governed by their existing terms. To the extent that any such awards are forfeited or lapse unexercised or are repurchased, the shares of common stock subject to such awards will become available for issuance under the 2014Plan.

(2)

Our board of directors adopted, and our stockholders approved, the 2014 Plan. The 2014 Plan provides that the number of shares available for issuance under the 2014 Plan will be increased on the first day of each fiscal year beginning with the 2015 fiscal year, in an amount equal to the lesser of (i) 2,500,000 shares, (ii) five percent (5.0%) of the outstanding shares of common stock on the lastday of the immediately preceding fiscal year or (iii) such other amount as our board of directors duringmaydetermine.

(3)

Our board of directors adopted, and our stockholders approved, the term2014 Employee Stock Purchase Plan (“ESPP”). The ESPPprovides that the number of his employment subject to board and/ or stockholder approval.

Pursuant toshares available for issuance under the employment agreementESPP will be increased on the first day of Dr. Weber, if we terminate each fiscal year beginning withthe employment of Dr. Weber other than for death, disability, or “cause” or Dr. Weber resigns for “good reason” (as such terms are defined2015 fiscal year, in Dr. Weber’s employment agreement), and, within 60 days following his termination, Dr. Weber executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Dr. Weber is entitled to receive (i) continuing payments of his then-current base salary for a period of 12 months, payable pursuant to our regular payroll procedures, (ii) an amount equal to a pro rata portionthe lesser of his target annual bonus for the year of termination, payable in accordance with our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for him(i) 800,000 shares, (ii) one and his respective dependents for up to 12 months, and (iv) additional vesting and exercisability as to any outstanding equity awards held by him as if he had remained our employee for an additional 24 months.

Pursuant to the employment agreement of Dr. Weber, if, within the 3 month period prior to or the 12 month period following a “change of control” (as defined in Dr. Weber’s employment agreement), the employment of Dr. Weber is terminated under the circumstances described in the above paragraph and, within 60 days following his termination, Dr. Weber executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Dr. Weber is entitled to receive (i) a lump sum payment equal to 18 months of his then-current base salary, payable pursuant to our regular payroll procedures, (ii) a lump sum payment equal to 150%one-half percent (1.5%) of the higheroutstanding shares of (x) his full target annual bonus forcommon stock on the last day of the immediately preceding fiscal year of termination, or (y) his full target annual bonus for the fiscal year in which the change of control occurs, payable pursuant to our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for him and his respective dependents for up to 18 months, and (iv) vesting acceleration of 100% with respect to any outstanding equity awards held by him on the date of his termination.

In the event any payment to Dr. Weber pursuant to his employment agreement would be subject to the excise tax imposed by Section 4999 of the Internal Revenue Code,such other amount as amended (the “Code”) (as a result of a payment being classified as a parachute payment under Section 280G of the Code), Dr. Weber will receive such payment as would entitle him to receive the greatestafter-tax benefit, even if it means that we pay him a lower aggregate payment so as to minimize or eliminate the potential excise tax imposed by Section 4999 of the Code.

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Paul E. Cayer

We have entered into an employment agreement with Mr. Cayer, effective as of August 13, 2014. The employment agreement has an initial term of 4 years, subject to earlier termination as provided in the employment agreement. Unless either party gives at least 90 days’ notice prior to the expiration of the initial term or the then-current additional term, as applicable, the employment agreement shall be renewed for an additional term of 1 year, in each case, commencing on the expiration of the initial term or the then-current additional term, as the case may be subject to earlier termination as provided in the employment agreement. In the event determined by our boardof a “change of control” (as defined in the employment agreement), if there is less than 12 months remaining in the initial term or then-current additional term, as applicable, the term will automatically extend until the12-monthdirectors. anniversary following the change of control. Pursuant to the agreement, Mr. Cayer will continue to serve as our Chief Financial and Business Officer on an “at will” basis. Mr. Cayer’s base salary was $395,185 during 2018 and remained unchanged for 2019. He is eligible to receive an annual performance bonus with the target amount determined as 40% of his annual base salary and eligible to participate in employee benefit or group insurance plans maintained from time to time by us.

Pursuant to the employment agreement of Mr. Cayer, if we terminate the employment of Mr. Cayer other than for death, disability, or “cause” or Mr. Cayer resigns for “good reason” (as such terms are defined in Mr. Cayer’s employment agreement), and, within 60 days following his termination, Mr. Cayer executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Mr. Cayer is entitled to receive (i) continuing payments of his then-current base salary for a period of 9 months, payable pursuant to our regular payroll procedures, (ii) an amount equal to a pro rata portion of his target annual bonus for the year of termination, payable in accordance with our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for him and his respective dependents for up to 9 months, and (iv) additional vesting and exercisability as to any outstanding equity awards held by him as if he had remained our employee for an additional 12 months.

Pursuant to the employment agreement of Mr. Cayer, if, within the 3 month period prior to or the 12 month period following a “change of control” (as defined in Mr. Cayer’s employment agreement), the employment of Mr. Cayer is terminated under the circumstances described in the above paragraph and, within 60 days following his termination, Mr. Cayer executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Mr. Cayer is entitled to receive (i) a lump sum payment equal to 12 months of his then-current base salary, payable pursuant to our regular payroll procedures, (ii) a lump sum payment equal to the higher of (x) his full target annual bonus for the fiscal year of termination, or (y) his full target annual bonus for the fiscal year in which the change of control occurs, payable pursuant to our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for him and his respective dependents for up to 12 months, and (iv) vesting acceleration of 100% with respect to any outstanding equity awards held by him on the date of his termination.

In the event any payment to Mr. Cayer pursuant to his employment agreement would be subject to the excise tax imposed by Section 4999 of the Code (as a result of a payment being classified as a parachute payment under Section 280G of the Code), Mr. Cayer will receive such payment as would entitle him to receive the greatestafter-tax benefit, even if it means that we pay him a lower aggregate payment so as to minimize or eliminate the potential excise tax imposed by Section 4999 of the Code.

Robert Michael Savel, II

We have entered into an employment agreement with Mr. Savel, effective as of July 31, 2014. The employment agreement has an initial term of 4 years, subject to earlier termination as provided in the employment agreement. Unless either party gives at least 90 days’ notice prior to the expiration of the initial term or the then-current additional term, as applicable, the employment agreement shall be renewed for an additional term of 1 year, in each case, commencing on the expiration of the initial term or the then-current additional term,

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as the case may be, subject to earlier termination as provided in the employment agreement. In the event of a “change of control” (as defined in the employment agreement), if there is less than 12 months remaining in the initial term or then-current additional term, as applicable, the term will automatically extend until the12-month anniversary following the change of control. Pursuant to the agreement, Mr. Savel will continue to serve as our Chief Technology Officer on an “at will” basis. Mr. Savel’s base salary was $355,000 during 2018 and remained unchanged for 2019. He is eligible to receive an annual performance bonus with the target amount determined as 40% of his annual base salary and eligible to participate in employee benefit or group insurance plans maintained from time to time by us.

Pursuant to the employment agreement of Mr. Savel, if we terminate the employment of Mr. Savel other than for death, disability, or “cause” or Mr. Savel resigns for “good reason” (as such terms are defined in Mr. Savel’s employment agreement), and, within 60 days following his termination, Mr. Savel executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Mr. Savel is entitled to receive (i) continuing payments of his then-current base salary for a period of 9 months, payable pursuant to our regular payroll procedures, (ii) an amount equal to a pro rata portion of his target annual bonus for the year of termination, payable in accordance with our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for his and his respective dependents for up to 9 months, and (iv) additional vesting and exercisability as to any outstanding equity awards held by him as if he had remained our employee for an additional 12 months.

Pursuant to the employment agreement of Mr. Savel, if, within the 3 month period prior to or the 12 month period following a “change of control” (as defined in Mr. Savel’s employment agreement), the employment of Mr. Savel is terminated under the circumstances described in the above paragraph and, within 60 days following his termination, Mr. Savel executes a waiver and release of claims in our favor and resigns from all positions he may hold as an officer or director, Mr. Savel is entitled to receive (i) a lump sum payment equal to 12 months of his then-current base salary, payable pursuant to our regular payroll procedures, (ii) a lump sum payment equal to the higher of (x) his full target annual bonus for the fiscal year of termination, or (y) his full target annual bonus for the fiscal year in which the change of control occurs, payable pursuant to our regular payroll procedures, (iii) reimbursement of premiums to maintain group health insurance continuation benefits pursuant to “COBRA” for his and his respective dependents for up to 12 months, and (iv) vesting acceleration of 100% with respect to any outstanding equity awards held by him on the date of his termination.

In the event any payment to Mr. Savel pursuant to his employment agreement would be subject to the excise tax imposed by Section 4999 of the Code (as a result of a payment being classified as a parachute payment under Section 280G of the Code), Mr. Savel will receive such payment as would entitle him to receive the greatestafter-tax benefit, even if it means that we pay him a lower aggregate payment so as to minimize or eliminate the potential excise tax imposed by Section 4999 of the Code.

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Equity Compensation Plan Information

The following table provides information as of December 31, 2019 with respect to shares of our common stock that may be issued under our existing equity compensation plans.

Plan Category

  Number of
Securities to be
Issued upon
Exercise of
Outstanding
Options,
Restricted
Stock Units
and Rights
  Weighted Average
Exercise Price of
Outstanding Options

and Rights
   Number of Securities
Remaining Available
for Future Issuance
Under Equity
Compensation Plans
(Excluding Securities
Reflected in the first
Column)
 

Equity compensation plans approved by security holders

     

2010 Equity Incentive Plan (1)

   1,475,531(4)  $3.44    —   

2014 Equity Incentive Plan (2)

   6,019,598(5)  $4.67    3,548,214 

2014 Employee Stock Purchase Plan (3)

   —     —      1,977,215 

Equity compensation plans not approved by security holders

   —     —      —   

TOTAL

   7,495,129  $4.43    5,525,429 

(1)

Our board of directors adopted, and our stockholders approved, the 2010 Equity Incentive Plan, as amended (“2010 Plan”). As a result of our initial public offering and the adoption of the 2014 Equity Incentive Plan (“2014 Plan”), we no longer grant awards under the 2010 Plan; however, all outstanding options issued pursuant to the 2010 Plan continue to be governed by their existing terms. To the extent that any such awards are forfeited or lapse unexercised or are repurchased, the shares of common stock subject to such awards will become available for issuance under the 2014 Plan.

(2)

Our board of directors adopted, and our stockholders approved, the 2014 Plan. The 2014 Plan provides that the number of shares available for issuance under the 2014 Plan will be increased on the first day of each fiscal year beginning with the 2015 fiscal year, in an amount equal to the least of (i) 2,500,000 shares, (ii) five percent (5.0%) of the outstanding shares of common stock on the last day of the immediately preceding fiscal year or (iii) such other amount as our board of directors may determine.

(4)

Consists of options to purchase 1,297,478shares.

(3)

Our board of directors adopted, and our shareholders approved, the 2014 Employee Stock Purchase Plan (“ESPP”). The ESPP provides that the number of shares available for issuance under the ESPP will be increased on the first day of each fiscal year beginning with the 2015 fiscal year, in an amount equal to the least of (i) 800,000 shares, (ii) one andone-half

(5)

Consists of options to purchase 8,545,266 shares. percent (1.5%) of the outstanding shares of common stock on the last day of the immediately preceding fiscal year or (iii) such other amount as may be determined by our board of directors.

(4)

Consists of options to purchase 1,475,531 shares.

(5)

Consists of options to purchase 6,019,598 shares.

 

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SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth certain information with respect to the beneficial ownership of our common stock as of March 31, 2020 for:

each of our directors and nominees for director;


SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT

The following table sets forth certain information with respect to the beneficial ownership of our common stock as of March 31, 2021 for:

each of our directors and nominees fordirector;

each of our named executiveofficers;

all of our current directors and executive officers as a group;and

each person or group who beneficially owned more than 5% of our commonstock.

We have determined beneficial ownership in accordance with the rules of the SEC and the information is not necessarily indicative of beneficial ownership for any other purpose. Unless otherwise indicated below, to our knowledge, the persons and entities named in the table have sole voting and sole investment power with respect to all shares that they beneficially owned, subject to community property laws where applicable.

We have based our calculation of the percentage of beneficial ownership on 48,319,202 shares of our common stock outstanding as of March 31, 2021. We have deemed shares of our common stock subject to stock options that are currently exercisable or exercisable within 60 days of March 31, 2021, to be outstanding and to be beneficially owned by the person holding the stock option for the purpose of computing the percentage ownership of that person. We did not deem these shares outstanding, however, for the purpose of computing the percentage ownership of any other person.

Unless otherwise indicated, the address of each beneficial owner listed in the table below is c/o Otonomy, Inc., 4796 Executive Drive, San Diego, California 92121.

Name of Beneficial Owner

 

Number of

Shares

Beneficially

Owned

 

 

Percentage of

Shares

Beneficially

Owned

 

5% Stockholders:

 

 

 

 

 

 

 

 

Entities affiliated with Baker Bros. Advisors LP (1)

 

 

7,220,074

 

 

 

13.8

%

Federated Hermes, Inc. (2)

 

 

4,856,200

 

 

 

10.1

%

Entities affiliated with OrbiMed Advisors LLC (3)

 

 

3,250,000

 

 

 

6.7

%

Sofinnova Investments, Inc. (4)

 

 

2,620,668

 

 

 

5.4

%

Cormorant Asset Management, LP (5)

 

 

2,600,000

 

 

 

5.4

%

Executive Officers and Directors:

 

 

 

 

 

 

 

 

David A. Weber, Ph.D. (6)

 

 

2,370,221

 

 

 

4.7

%

Paul E. Cayer (7)

 

 

796,454

 

 

 

1.6

%

Robert M. Savel, II (8)

 

 

557,535

 

 

 

1.1

%

James Breitmeyer, M.D., Ph.D (9)

 

 

40,833

 

 

*

 

Vickie Capps (10)

 

 

127,242

 

 

*

 

Ciara Kennedy, Ph.D. (11)

 

 

11,666

 

 

*

 

Jay Lichter, Ph.D. (12)

 

 

80,000

 

 

*

 

Iain McGill (13)

 

 

75,000

 

 

*

 

Theodore R. Schroeder (14)

 

 

90,000

 

 

*

 

All current directors and executive officers as a group (9

   persons) (15)

 

 

4,148,951

 

 

 

7.9

%

 

each of our named executive officers;*

all of our current directors and executive officers as a group; and

each person or group who beneficially owned more than 5% of our common stock.

We have determined beneficial ownership in accordance with the rules of the SEC and the information is not necessarily indicative of beneficial ownership for any other purpose. Unless otherwise indicated below, to our knowledge, the persons and entities named in the table have sole voting and sole investment power with respect to all shares that they beneficially owned, subject to community property laws where applicable.

We have based our calculation of the percentage of beneficial ownership on 30,814,211 shares of our common stock outstanding as of March 31, 2020. We have deemed shares of our common stock subject to stock options that are currently exercisable or exercisable within 60 days of March 31, 2020, to be outstanding and to be beneficially owned by the person holding the stock option for the purpose of computing the percentage ownership of that person. We did not deem these shares outstanding, however, for the purpose of computing the percentage ownership of any other person.

Unless otherwise indicated, the address of each beneficial owner listed in the table below is c/o Otonomy, Inc., 4796 Executive Drive, San Diego, California 92121.

Name of Beneficial Owner

  Number of
Shares
Beneficially
Owned
   Percentage
of Shares
Beneficially
Owned
 
5% Stockholders:    

Entities Affiliated with Avalon (1)

   2,297,361    7.5

TPG Biotechnology Partners III, L.P. (2)

   2,159,335    7.0

Renaissance Technologies LLC (3)

   1,939,965    6.3

First Manhattan Co (4)

   1,572,733    5.1
Executive Officers and Directors:    

David A. Weber, Ph.D. (5)

   1,896,349    5.8

Paul E. Cayer (6)

   565,605    1.8

Robert Michael Savel, II (7)

   369,154    1.2

James Breitmeyer, M.D., Ph.D (8)

   11,666    * 

Vickie Capps (9)

   109,742    * 

Ciara Kennedy, Ph.D.

   —      —   

Jay Lichter, Ph.D. (10)

   2,359,861    7.6

Iain McGill (11)

   57,500    * 

Theodore R. Schroeder (12)

   72,500    * 

All current directors and executive officers as a group (9 persons) (13)

   5,442,377    16.1

*

Represents beneficial ownership of less than one percent (1%) of the outstanding shares of our common stock.

(1)

Based on information set forth in a Schedule 13D filed with the SEC by entities affiliated with Avalon Ventures on August 29, 2014 and a Form 4 filed with the SEC on behalf of Jay Lichter, Ph.D. on September 5, 2017, these shares consist of (i) 32,209 shares issued upon the exercise of warrants held by Avalon Ventures VIII, L.P. (“Avalon VIII”), (ii) 1,450,179 shares held by Avalon Ventures VIII, L.P. (“Avalon VIII”) and (iii) 814,973 shares held by Avalon Ventures X, L.P. (“Avalon X”). Kevin Kinsella, Stephen Tomlin, Richard Levandov, Braden Bohrmann and Jay Lichter, Ph.D. are managing directors of Avalon X and Avalon VIII and share voting and dispositive power over the shares held by each entity. The address for these entities is 1134 Kline Street, La Jolla, California 92037.

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(2)

Based on information set forth in a Schedule 13G filed with the SEC by individuals and entities affiliated with TPG Biotechnology Partners III, L.P. (“TPG Biotech”) on February 13, 2015, these shares consist of 2,159,335 shares held by TPG Biotech. The general partner of TPG Biotech is TPG Biotechnology GenPar III, L.P., a Delaware limited partnership, whose general partner is TPG Biotechnology GenPar III Advisors, LLC, a Delaware limited liability company, whose sole member is TPG Holdings I, L.P., a Delaware limited partnership, whose general partner is TPG HoldingsI-A, LLC, a Delaware limited liability company, whose sole member is TPG Group Holdings (SBS), L.P., a Delaware limited partnership, whose general partner is TPG Group Holdings (SBS) Advisors, Inc., a Delaware corporation. David Bonderman and James G. Coulter are officers and sole stockholders of TPG Group Holdings (SBS) Advisors, Inc. and may therefore be deemed to be the beneficial owners of the securities held by the TPG Biotech. The address of each of TPG Group Holdings (SBS) Advisors, Inc. and Messrs. Bonderman and Coulter is c/o TPG Global, LLC, 301 Commerce Street, Suite 3300, Fort Worth, Texas 76102.

(3)

Based on information set forth in a Schedule 13G filed with the SEC by Renaissance Technologies LLC (“RTC”) on February 12, 2020, these shares consist of 1,939,965 shares held by RTC. Renaissance Technologies Holding Corporation (“RTHC”) is the majority owner of RTC, and as such, RTC and RTHC have sole voting power as to 1,756,603 shares, sole dispositive power as to 1,937,927 shares and shared dispositive power as to 2,038 shares. The business address for RTC and RTHC is 800 Third Avenue, New York, New York 10022.

(4)

Based on information set forth in a Schedule 13G/A filed with the SEC by First Manhattan Co (“First Manhattan”), an investment adviser registered under Section 203 of the Investment Advisers Act of 1940 and broker or dealer registered under section 15 of the Exchange Act, on February 4, 2020, these shares consist of 1,572,733 shares over which First Manhattan has sole voting and dispositive power. The address for these entities is 399 Park Avenue, New York, New York 10022.

(5)

Consists of (i) 1,864,769 shares held by Dr. Weber issuable upon the exercise of options that are exercisable within 60 days of March 31, 2020, (ii) 4,812 shares held by The Weber Trust Dated March 9, 2005, for which Dr. Weber serves as a trustee and (iii) 26,768 shares held of record by Dr. Weber.

(6)

Consists of (i) 542,179 shares held by Mr. Cayer issuable upon the exercise of options that are exercisable within 60 days of March 31, 2020 and (ii) 23,426 shares held of record by Mr. Cayer.

(7)

Consists of (i) 352,720 shares held by Mr. Savel issuable upon the exercise of options that are exercisable within 60 days of March 31, 2020 and (ii) 16,434 shares held of record by Mr. Savel.

(8)

Consists of 11,666 shares held by Dr. Breitmeyer issuable upon the exercise of options that are exercisable within 60 days of March 31, 2020.

(9)

Consists of (i) 62,500 shares held by Ms. Capps issuable upon the exercise of options that are exercisable within 60 days of March 31, 2020, (ii) 45,642 shares held of record by Ms. Capps and (iii) 1,600 shares held of record by her spouse.

(10)

Consists of (i) 62,500 shares held by Dr. Lichter issuable upon the exercise of options that are exercisable within 60 days of March 31, 2020 and (ii) the shares listed in footnote (1) above, which are held by entities affiliated with Avalon Ventures. Dr. Lichter shares voting and dispositive power with respect to these shares.

(11)

Consists of 57,500 shares held by Mr. McGill issuable upon the exercise of options that are exercisable within 60 days of March 31, 2020.

(12)

Consists of 72,500 shares held by Mr. Schroeder issuable upon the exercise of options that are exercisable within 60 days of March 31, 2020.

(13)

Consists of (i) 2,416,043 shares held of record by our current executive officers and directors and (ii) 3,026,334 shares issuable upon the exercise of options exercisable within 60 days of March 31, 2020.

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RELATED PERSON TRANSACTIONS

We describe below transactions and series of similar transactions, since the beginning of our last fiscal year, to which we were a party or will be a party, in which:

the amounts involved exceeded or will exceed $120,000; and

any of our directors, nominees for director, executive officers or beneficial holders of more than 5% of our outstanding capital stock, or any immediate family member of, or person sharing the household with, any of these individuals or entities (each, a related person), had or will have a direct or indirect material interest.

Investors’ Rights Agreement

In connection with our sale and issuance of series D convertible preferred stock in April 2014, we entered into a third amended and restated investors’ rights agreement with the holdersSEC by Baker Bros. Advisors LP (“BBA”) on April 12, 2021, reporting beneficial ownership as of our convertible preferred stock, including Avalon Ventures and TPG Biotechnology Partners III, L.P. or entities affiliated with them and with which certainMarch 31, 2021, these shares consist of our directors are affiliated, Vickie Capps, a member of our board of directors, and an entity affiliated with David A. Weber, Ph.D., a member of our board directors and our President and Chief Executive Officer. This agreement provides, among other things, that certain holders of our common stock have the right to demand that we file a registration statement or request that their(i) 6,683,788 shares of our common stock be covereddirectly held by a registration statement that we are otherwise filing,Baker Brothers Life Sciences, L.P. (“Life Sciences”) as well as certain information rights and rights of first refusal.

Other Agreements

In addition to the indemnification required in our amended and restated certificate of incorporation and amended and restated bylaws, we have entered into an indemnification agreement with each member of our board of directors and each of our officers. These agreements provide for the indemnification of our directors and officers for certain expenses and liabilities incurred in connection with any action, suit, proceeding or alternative dispute resolution mechanism, or hearing, inquiry or investigation that may lead to the foregoing, to which they are a party, or are threatened to be made a party, by reason of the fact that they are or were a director, officer, employee, agent or fiduciary of our company, or any of our subsidiaries, by reason of any action or inaction by them while serving as an officer, director, agent or fiduciary, or by reason of the fact that they were serving at our request as a director, officer, employee, agent or fiduciary of another entity. In the case of an action or proceeding by or in the right of our company or any of our subsidiaries, no indemnification will be provided for any claim where a court determines that the indemnified party is prohibited from receiving indemnification. We believe that these charter and bylaw provisions and indemnification agreements are necessary to attract and retain qualified persons as directors and officers.

We have entered into employment agreements with certain of our executive officers that, among other things, provide for certain severance and change of control benefits. For a description of employment agreements with our named executive officers, see “Executive Compensation—Executive Employment Agreements.”

We have granted stock options to our named executive officers, other executive officers and certain of our directors. See “Executive Compensation—Executive Employment Agreements.”

Other than as described above, since January 1, 2019, we have not entered into any transactions, nor are there any currently proposed transactions, between us and a related party where the amount involved exceeds, or would exceed, $120,000, and in which any related person had or will have a direct or indirect material interest. We believe the terms of the transactions described above were comparable to terms we could have obtained inarm’s-length dealings with unrelated third parties.

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Policies and Procedures for Related Party Transactions

We have adopted a formal written policy providing that our audit committee will be responsible for reviewing “related party transactions,” which are transactions (i) in which we are or will be a participant, (ii) in which the aggregate amount involved exceeds or may be expected to exceed $120,000 and (iii) in which a related person has or will have a direct or indirect interest. For purposes of this policy, a related person will be defined as a director, nominee for director, executive officer, or greater than 5% beneficial ownershares of our common stock that may be acquired upon exercise of pre-funded warrants held by Life Sciences, subject to the limitations on exercise described below and (ii) 536,286 shares of our common stock directly held by 667, L.P. (“667”, and together with Life Sciences, the “Funds”) as well as shares of our common stock that may be acquired upon exercise of pre-funded warrants held by 667, subject to the limitations on exercise described below. The pre-funded warrants held by the Funds are only exercisable to the extent that after giving effect to such exercise the holders thereof, their affiliates and any persons who are members of a Section 13(d) group with the holders or their affiliates would beneficially own in the aggregate, for purposes of Rule 13d-3 under the Exchange Act, no more than 4.99% of our outstanding common stock, which percentage can be increased not in excess of 19.99% or decreased by the Funds upon written request to us, with such increase


or decrease becoming effective on the 61st day after such notice is delivered to us. As a result of this restriction, the pre-funded warrants held by the Funds are not presently exercisable and the number of shares of common stock that may be issued upon exercise of the pre-funded warrants by the Funds may change depending upon changes in our outstanding common stock. Pursuant to the management agreements, as amended, among BBA, the Funds and their immediate family members. In reviewing any related party transaction, our auditrespective general partners, the Funds’ respective general partners relinquished to BBA all discretion and authority with respect to the investment and voting power of the securities held by the Funds and thus BBA has complete and unlimited discretion and authority with respect to the Funds’ investments and voting power over investments. Baker Bros. Advisors (GP) LLC (the “Adviser GP”), Felix J. Baker and Julian C. Baker as managing members of the Adviser GP, and BBA may be deemed to be beneficial owners of securities directly held by the Funds. The principal business address of the entities affiliated with BBA is c/o Baker Bros. Advisors LP, 860 Washington Street, 3rd Floor, New York, New York 10014.

(2)

Based on information set forth in a Schedule 13G/A filed with the SEC by Federated Hermes, Inc. (“Federated Hermes”) on February 10, 2021, these shares consist of 4,856,200 shares held by and over which Federated Hermes has sole voting and dispositive power.  Federated Hermes is the parent holding company of Federated Equity Management Company of Pennsylvania and Federated Global Investment Management Corp.(the “Investment Advisers”), which act as investment advisers to registered investment companies and separate accounts that own the reported shares. The Investment Advisers are wholly owned subsidiaries of FII Holdings, Inc., which is wholly owned subsidiary of Federated Hermes. All of Federated Hermes’ outstanding voting stock is held in the Voting Shares Irrevocable Trust (the “Trust”) for which Thomas R. Donahue, Rhodora J. Donahue and J. Christopher Donahue act as trustees (collectively, the “Trustees”).  The Trustees have collective voting control that they can exercise over Federated Hermes. Federated Hermes, the Trust, and each of the Trustees expressly disclaim beneficial ownership of the reported shares. The principal business address of Federated Hermes is 1001 Liberty Avenue, Pittsburg, Pennsylvania 15222-3779.

(3)

Based on information set forth in a Schedule 13G filed with the SEC by OrbiMed Advisors LLC (“OrbiMed Advisors”) on February 12, 2021, these shares consist of (i) 2,480,800 shares held by and over which OrbiMed Capital LLC (“OrbiMed Capital”) has sole voting and dispositive power and (ii) 769,200 shares held by and over which OrbiMed Advisors has shared voting and dispositive power.  OrbiMed Advisors and OrbiMed Capital hold shares on behalf of other persons who have the right to receive or the power to direct the receipt of dividends from, or proceeds from the sale of, such securities. No one such other person’s interest in the securities whose ownership is reported here relates to more than five percent of the class. OrbiMed Advisors and OrbiMed Capital exercise investment and voting power over the shares through a management committee comprised of Carl L.Gordon, Sven H. Borho, and Jonathan T. Silverstein, each of whom disclaims beneficial ownership of such shares. The address for OrbiMed Advisors and OrbiMed Capital is 601 Lexington Avenue, 54th Floor, New York, NY 10022.

(4)

Based on information set forth in a Schedule 13G filed with the SEC by Sofinnova Investments, Inc. (“Sofinnova Investments”) on February 16, 2021, these shares consist of 4,856,200 shares held by and over which Sofinnova Investments has sole voting and dispositive power.  The shares are beneficially owned by investment funds for which Sofinnova BioEquities GP, LLC (“Sofinnova BioEquities”) exercises investment discretion with respect to considersuch shares. Sofinnova Investments serves as investment advisor to Sofinnova BioEquities.  The address for Sofinnova Investments is 3000 Sand Hill Road, Building 4, Suite 250, Menlo Park, CA 94025.

(5)

Based on information set forth in a Schedule 13G/A filed with the relevant factsSEC by Cormorant Asset Management, LP (“Cormorant LP”) on February 16, 2021, these shares consist of 2,600,000 shares held by Cormorant LP. Shares held by Cormorant LP represent shares which are beneficially owned by Cormorant Global Healthcare Master Fund, LP (the “Master Fund”) and circumstances availablea managed account (the “Cormorant Account”) with shared voting and dispositive power.  Cormorant Global Healthcare GP, LLC (“Cormorant Global”) serves as the general partner of the Master Fund. Cormorant LP serves as the investment manager to our audit committee, including, whether the transaction is on terms no less favorable than terms generally availableMaster Fund and the Cormorant Account. Bihua Chen serves as the managing member of Cormorant Global and the general partner of Cormorant LP. Each of Cormorant LP, the Master Fund, the Cormorant Account, Cormorant Global, and Bihua Chen disclaims beneficial ownership of such shares except to an unaffiliated third party under the same or similar circumstances, and the extent of its or his pecuniary interest therein. The address of the related party’s interest inentities affiliated with Cormorant LP is 200 Clarendon Street, 52nd Floor, Boston, MA 02116.

(6)

Consists of (i) 2,338,641 shares held by Dr. Weber issuable upon the transaction. Under this policy, all related party transactions may be consummated or continued only if approved or ratifiedexercise of options that are exercisable within 60 days of March31, 2021, (ii) 21,876 shares held by The Weber Trust Dated March 9, 2005, for which Dr. Weber serves as trustee and (iii) 9,704 shares held of record by Dr. Weber.

(7)

Consists of (i) 768,028 shares held by Mr. Cayer issuable upon the exercise of options that are exercisable within 60 days of March31, 2021 and (ii) 28,426 shares held of record by Mr.Cayer.

(8)

Consists of (i) 536,101 shares held by Mr. Savel issuable upon the exercise of options that are exercisable within 60 days of March31, 2021 and (ii) 21,434 shares held of record by Mr.Savel.

(9)

Consists of 40,833 shares held by Dr. Breitmeyer issuable upon the exercise of options that are exercisable within 60 days of March31, 2021.

(10)

Consists of (i) 80,000 shares held by Ms. Capps issuable upon the exercise of options that are exercisable within 60 days of March31, 2021, (ii) 45,642 shares held of record by Ms. Capps and (iii) 1,600 shares held of record by herspouse.

(11)

Consists of 11,666 shares held by Dr. Kennedy issuable upon the exercise of options that are exercisable within 60 days of March 31, 2021.

(12)

Consists of 80,000 shares held by Dr. Lichter issuable upon the exercise of options that are exercisable within 60 days of March 31, 2021.

(13)

Consists of 75,000 shares held by Mr. McGill issuable upon the exercise of options that are exercisable within 60 days of March31, 2021.

(14)

Consists of 90,000 shares held by Mr. Schroeder issuable upon the exercise of options that are exercisable within 60 days of March31, 2021.

(15)

Consists of (i) 128,682 shares held of record by our audit committee.

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OTHER MATTERS

Delinquent Section 16(a) Reports

Section 16(a) of the Exchange Act requires that ourcurrent executive officers and directors and persons who own more than 10%(ii) 4,020,269 shares issuable uponthe exercise of our common stock, file reports of ownership and changes of ownership with the SEC. Such directors, executive officers and 10% stockholders are required by SEC regulation to furnish us with copies of all Section 16(a) forms they file.

SEC regulations require us to identify in this proxy statement anyone who filed a required report late during the most recent fiscal year. Based on our review of forms we received, or written representations from reporting persons stating that they were not required to file these forms, we believe that during our fiscal year ended December 31, 2019, all Section 16(a) filing requirements were satisfied on a timely basis.

Fiscal Year 2019 Annual Report and SEC Filings

Our financial statements for our fiscal year ended December 31, 2019 are included in our Annual Report on Form10-K filed with the SEC on February 27, 2020 (FileNo. 001-36591). This proxy statement and our Annual Report are posted in the Financial Information section of the Investor Relations webpage at http:// investors.otonomy.com and are available from the SEC at its website at www.sec.gov. You may also obtain a copy of our annual report without charge by sending a written request to Otonomy, Inc., Attention: Investor Relations, 4796 Executive Drive, San Diego, California 92121.

Company Website

We maintain a website at www.otonomy.com. Information contained on, or that can be accessed through, our website is not intended to be incorporated by reference into this proxy statement, and references to our website address in this proxy statement are inactive textual references only.

-39-


PROPOSALS OF STOCKHOLDERS FOR 2021 ANNUAL MEETING

Stockholders who wish to present proposals for inclusion in the proxy materials to be distributed in connection with next year’s annual meeting must submit their proposals so that they are received at Otonomy’s principal executive offices no later than January 6, 2021. Pursuant to the rules promulgated by the SEC, simply submitting a proposal does not guarantee that it will be included.

In order to be properly brought before the 2021 annual meeting of stockholders, a stockholder’s notice of a matter the stockholder wishes to present, or the person or persons the stockholder wishes to nominate as a director, must be delivered to the Secretary of Otonomy at its principal executive offices not less than 45 nor more than 75 days before the first anniversary of the date on which Otonomy first mailed its proxy materials or a notice of availability of proxy materials (whichever is earlier) for the preceding year’s annual meeting. As a result, any notice given by a stockholder pursuant to these provisions of our bylaws must be received no earlier than February 19, 2021, and no later than March 22, 2021, unless our annual meeting date occurs more than 30 days before oroptions exercisable within 60 days after June 23, 2021. In that case, we must receive proposals not earlier than the close of business on the 120th day prior to the date of the 2021 annual meeting and not later than the close of business on the later of the 90th day prior to the date of the annual meeting or the 10th day following the day on which we first make a public announcement of the date of the meeting.March 31,2021.


RELATED PERSON TRANSACTIONS

We describe below transactions and series of similar transactions, since the beginning of our last fiscal year, to which we were a party or will be a party, in which:

the amounts involved exceeded or will exceed $120,000;and

any of our directors, nominees for director, executive officers or beneficial holders of more than 5% of our outstanding capital stock, or any immediate family member of, or person sharing the household with, any of these individuals or entities (each, a related person), had or will have a direct or indirect materialinterest.

Investors’ Rights Agreement

In connection with our sale and issuance of series D convertible preferred stock in April 2014, we entered into a third amended and restated investors’ rights agreement with the holders of our convertible preferred stock, including Vickie Capps, a member of our board of directors, and an entity affiliated with David A. Weber, Ph.D., a member of our board directors and our President and Chief Executive Officer. This agreement provides, among other things, that certain holders of our common stock have the right to demand that we file a registration statement or request that their shares of our common stock be covered by a registration statement that we are otherwise filing, as well as certain information rights and rights of first refusal.

Other Agreements

In addition to the indemnification required in our amended and restated certificate of incorporation and amended and restated bylaws, we have entered into an indemnification agreement with each member of our board of directors and each of our officers. These agreements provide for the indemnification of our directors and officers for certain expenses and liabilities incurred in connection with any action, suit, proceeding or alternative dispute resolution mechanism, or hearing, inquiry or investigation that may lead to the foregoing, to which they are a party, or are threatened to be made a party, by reason of the fact that they are or were a director, officer, employee, agent or fiduciary of our company, or any of our subsidiaries, by reason of any action or inaction by them while serving as an officer, director, agent or fiduciary, or by reason of the fact that they were serving at our request as a director, officer, employee, agent or fiduciary of another entity. In the case of an action or proceeding by or in the right of our company or any of our subsidiaries, no indemnification will be provided for any claim where a court determines that the indemnified party is prohibited from receiving indemnification. We believe that these charter and bylaw provisions and indemnification agreements are necessary to attract and retain qualified persons as directors and officers.

We have entered into employment agreements with certain of our executive officers that, among other things, provide for certain severance and change of control benefits. For a description of employment agreements with our named executive officers, see “Executive Compensation—Executive Employment Agreements.”

We have granted stock options to our named executive officers, other executive officers and certain of our directors. See “Executive Compensation—Executive Employment Agreements.”

Other than as described above, since January 1, 2020, we have not entered into any transactions, nor are there any currently proposed transactions, between us and a related party where the amount involved exceeds, or would exceed, $120,000, and in which any related person had or will have a direct or indirect material interest. We believe the terms of the transactions described above were comparable to terms we could have obtained in arm’s-length dealings with unrelated third parties.

Policies and Procedures for Related Party Transactions

We have adopted a formal written policy providing that our audit committee will be responsible for reviewing “related party transactions,” which are transactions (i) in which we are or will be a participant, (ii) in which the aggregate amount involved exceeds or may be expected to exceed $120,000 and (iii) in which a related person has or will have a direct or indirect interest. For purposes of this policy, a related person will be defined as a director, nominee for director, executive officer, or greater than 5% beneficial owner of our common stock and their immediate family members. In reviewing any related party transaction, our audit committee is to consider the relevant facts and circumstances available to our audit committee, including, whether the transaction is on terms no less favorable than terms generally available to an unaffiliated third party under the same or similar circumstances, and the extent of the related party’s interest in the transaction. Under this policy, all related party transactions may be consummated or continued only if approved or ratified by our audit committee.


OTHER MATTERS

Delinquent Section 16(a) Reports

Section 16(a) of the Exchange Act requires that our executive officers and directors, and persons who own more than 10% of our common stock, file reports of ownership and changes of ownership with the SEC. Such directors, executive officers and 10% stockholders are required by SEC regulation to furnish us with copies of all Section 16(a) forms they file.

SEC regulations require us to identify in this proxy statement anyone who filed a required report late during the most recent fiscal year. Based on our review of forms we received, or written representations from reporting persons stating that they were not required to file these forms, we believe that during our fiscal year ended December 31, 2020, all Section 16(a) filing requirements were satisfied on a timely basis.

Fiscal Year 2020 Annual Report and SEC Filings

Our financial statements for our fiscal year ended December 31, 2020 are included in our Annual Report on Form 10-K filed with the SEC on February 11, 2021 (File No. 001-36591). This proxy statement and our Annual Report are posted in the Financial Information section of the Investor Relations webpage at http://investors.otonomy.com and are available from the SEC at its website at www.sec.gov. You may also obtain a copy of our annual report without charge by sending a written request to Otonomy, Inc., Attention: Investor Relations, 4796 Executive Drive, San Diego, California 92121.

Company Website

We maintain a website at www.otonomy.com. Information contained on, or that can be accessed through, our website is not intended to be incorporated by reference into this proxy statement, and references to our website address in this proxy statement are inactive textual references only.


PROPOSALS OF STOCKHOLDERS FOR 2022 ANNUAL MEETING

Stockholders who wish to present proposals for inclusion in the proxy materials to be distributed in connection with next year’s annual meeting must submit their proposals so that they are received at Otonomy’s principal executive offices no later than January 6, 2022. Pursuant to the rules promulgated by the SEC, simply submitting a proposal does not guarantee that it will be included.

In order to be properly brought before the 2022 annual meeting of stockholders, a stockholder’s notice of a matter the stockholder wishes to present, or the person or persons the stockholder wishes to nominate as a director, must be delivered to the Secretary of Otonomy at its principal executive offices not less than 45 nor more than 75 days before the first anniversary of the date on which Otonomy first mailed its proxy materials or a notice of availability of proxy materials (whichever is earlier) for the preceding year’s annual meeting. As a result, any notice given by a stockholder pursuant to these provisions of our bylaws must be received no earlier than February 18, 2022, and no later than March 22, 2022, unless our annual meeting date occurs more than 30 days before or 60 days after June 22, 2022. In that case, we must receive proposals not earlier than the close of business on the 120th day prior to the date of the 2022 annual meeting and not later than the close of business on the later of the 90th day prior to the date of the annual meeting or the 10th day following the day on which we first make a public announcement of the date of the meeting.

To be in proper form, a stockholder’s notice must include the specified information concerning the proposal or nominee as described in our bylaws. A stockholder who wishes to submit a proposal or nomination is encouraged to seek independent counsel about our bylaws and SEC requirements. Otonomy will not consider any proposal or nomination that is not timely or otherwise does not meet the bylaws and SEC requirements for submitting a proposal or nomination.

Notices of intention to present proposals at the 2022 annual meeting of stockholders must be addressed to: Secretary, Otonomy, Inc., 4796 Executive Drive, San Diego, California 92121. We reserve the right to reject, rule out of order, or take other appropriate action with respect to any proposal that does not comply with these and other applicable requirements.

Notices of intention to present proposals at the 2021 annual meeting of stockholders must be addressed to: Secretary, Otonomy, Inc., 4796 Executive Drive, San Diego, California 92121. We reserve the right to reject, rule out of order, or take other appropriate action with respect to any proposal that does not comply with these and other applicable requirements.

*        *        ***

The board of directors does not know of any other matters to be presented at the Annual Meeting. If any additional matters are properly presented at the Annual Meeting, the persons named on the enclosed proxy card will have discretion to vote the shares of common stock they represent in accordance with their own judgment on such matters.

It is important that your shares of common stock be represented at the Annual Meeting, regardless of the number of shares that you hold. You are, therefore, urged to vote over the Internet or by telephone as instructed on the enclosed proxy card or execute and return, at your earliest convenience, the enclosed proxy card in the envelope that has also been provided.

THE BOARD OF DIRECTORS

San Diego, California

April 27, 2020

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LOGO

OTONOMY, INC.

4796 EXECUTIVE DRIVE

SAN DIEGO, CA 92121

VOTE BY INTERNET - www.proxyvote.com

Use the Internet to transmit your voting instructions and for electronic delivery of information. Vote by 11:59 P.M. ET on 06/22/2020. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form.

ELECTRONIC DELIVERY OF FUTURE PROXY MATERIALS

If you would like to reduce the costs incurred by our company in mailing proxy materials, you can consent to receiving all future proxy statements, proxy cards and annual reports electronically via e-mail or the Internet. To sign up for electronic delivery, please follow the instructions above to vote using the Internet and, when prompted, indicate that you agree to receive or access proxy materials electronically in future years.

VOTE BY PHONE - 1-800-690-6903

Use any touch-tone telephone to transmit your voting instructions. Vote by 11:59 P.M. ET on 06/22/2020. Have your proxy card in hand when you call and then follow the instructions.

VOTE BY MAIL

Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.28, 2021

 

 

TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS:


 

KEEP THIS PORTION FOR YOUR RECORDS

— — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — —

DETACH AND RETURN THIS PORTION ONLY

THIS    PROXY    CARD    IS    VALID     ONLY    WHEN    SIGNED    AND    DATED.

 

For

All

Withhold

All

For All

Except

To withhold authority to vote for any individual nominee (s), mark “For All Except” and write the number (s) of the nominee (s) on the line below.

The Board of Directors recommends you vote FOR the following:

1.

Election of Directors

Nominees
01Vickie Capps                                 02    Ciara Kennedy, Ph.D.                                          03    Iain McGill

The Board of Directors recommends you vote FOR the following proposal:ForAgainstAbstain
2.The approval of, on a non-binding advisory basis, the compensation paid to our named executive officers, as disclosed in the proxy statement.

NOTE:In the discretion of the named proxy holders regarding any other matters properly presented for a vote at the Annual Meeting.

The Board of Directors recommends you vote 1 YEAR on the following proposal:1 year2 years3 yearsAbstain

We currently intend to hold our Annual Meeting in person. However, we are actively monitoring the coronavirus (COVID-19) pandemic and we are sensitive to the health, safety and travel concerns of our stockholders and federal, state and local government recommendations and restrictions imposed in response to the pandemic. Accordingly, in the event it is not possible or advisable to hold our Annual Meeting at a physical location, we will announce alternative arrangements, including holding our Annual Meeting virtually at www.virtualshareholdermeeting.com/OTIC2020, as soon as practicable, by press release, which will be posted to our webpage at investors.otonomy.com/news-releases.

3.

The approval of, on a non-binding advisory basis, the frequency of future non-binding stockholder advisory votes to approve the compensation paid to our named executive officers.

The Board of Directors recommends you vote FOR the following proposal:

ForAgainstAbstain

LOGO

4.

The ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2020.

Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer.

Signature [PLEASE SIGN WITHIN BOX]Date  Signature (Joint Owners)Date  


Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting:

The Notice and Proxy Statement and 10-K Wrap are available atwww.proxyvote.com

— — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — — —

 

LOGO

OTONOMY, INC.

Annual Meeting of Stockholders

June 23, 2020 8:00 a.m., PDT

This proxy is solicited by the Board of Directors

The stockholders hereby appoint David A. Weber, Ph.D. and Paul E. Cayer, or one of them, as proxies, each with the power to appoint his substitute, and hereby authorizes them to represent and to vote, as designated on the reverse side of this ballot, all of the shares of common stock of OTONOMY, INC that the stockholder is entitled to vote at the Annual Meeting of Stockholders to be held at 8:00 a.m., PDT on June 23, 2020, at the corporate offices of Otonomy, Inc., 4796 Executive Dr., San Diego, CA 92121, or virtually at www.virtualshareholdermeeting.com/OTIC2020, as needed, and any adjournment or postponement thereof.

This proxy, when properly executed, will be voted in the manner directed herein. If no such direction is made, this proxy will be voted in accordance with the Board of Directors’

OTONOMY, INC.  4796 EXECUTIVE DRIVE  SAN DIEGO, CA 92121  D53116-P52171  For All  Withhold All  For All Except  To withhold authority to vote for any individual nominee(s), mark "For All Except" and write the number(s) of the nominee(s) on the line below.  OTONOMY, INC.  The Board of Directors recommends you vote FOR the following: 1. Election of Directors  Nominees:  01 James B. Breitmeyer, M.D., Ph.D. 02 David A. Weber, Ph.D.  For  Against  Abstain  The Board of Directors recommends you vote FOR the following proposals:  2. The approval of, on a non-binding advisory basis, the compensation paid to our named executive officers, as disclosed in the proxy statement.  3. The ratification of the appointment of Ernst & Young LLP as our independent registered public accounting firm for our fiscal year ending December 31, 2021.  NOTE: In the discretion of the named proxy holders regarding any other matters properly presented for a vote at the Annual Meeting and any adjournment or postponement thereof.  Please sign exactly as your name(s) appear(s) hereon. When signing as attorney, executor, administrator, or other fiduciary, please give full title as such. Joint owners should each sign personally. All holders must sign. If a corporation or partnership, please sign in full corporate or partnership name by authorized officer. TO VOTE, MARK BLOCKS BELOW IN BLUE OR BLACK INK AS FOLLOWS: KEEP THIS PORTION FOR YOUR RECORDS THIS PROXY CARD IS VALID ONLY WHEN SIGNED AND DATED. DETACH AND RETURN THIS PORTION ONLY Signature [PLEASE SIGN WITHIN BOX] Date Signature (Joint Owners) Date   VOTE BY INTERNET  Before The Meeting - Go to www.proxyvote.com.  Use the Internet to transmit your voting instructions and for electronic delivery of information. Vote by 11:59 p.m. Eastern Time on June 21, 2021. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to create an electronic voting instruction form.  During The Meeting - Go to www.virtualshareholdermeeting.com/OTIC2021.  You may attend the meeting via the Internet and vote during the meeting. Have the information that is printed in the box marked by the arrow available and follow the instructions.  VOTE BY PHONE - 1-800-690-6903  Use any touch-tone telephone to transmit your voting instructions. Vote by 11:59 p.m. Eastern Time on June 21, 2021. Have your proxy card in hand when you call and then follow the instructions.  VOTE BY MAIL  Mark, sign and date your proxy card and return it in the postage-paid envelope we have provided or return it to Vote Processing, c/o Broadridge, 51 Mercedes Way, Edgewood, NY 11717.


OTONOMY, INC.  Annual Meeting of Stockholders  June 22, 2021 8:00 a.m., Pacific Time  This proxy is solicited by the Board of Directors  The undersigned stockholder hereby appoints David A. Weber, Ph.D. and Paul E. Cayer, or one of them, as proxies, each with the power to appoint his substitute, and hereby authorizes them to represent and to vote, as designated on the reverse side of this ballot, all of the shares of common stock of OTONOMY, INC. that the stockholder is entitled to vote at the Annual Meeting of Stockholders to be held virtually at 8:00 a.m., Pacific Time on June 22, 2021, and any adjournment or postponement thereof. The Annual Meeting of Stockholders will be conducted virtually via live webcast. You will be able to attend the Annual Meeting of Stockholders by visiting www.virtualshareholdermeeting.com/OTIC2021.  This proxy, when properly executed, will be voted in the manner directed herein. If no such direction is made, this proxy will be voted in accordance with the Board of Directors' recommendations.  Continued and to be signed on reverse side Important Notice Regarding the Availability of Proxy Materials for the Annual Meeting: The Notice and Proxy Statement and 10-K Wrap are available at www.proxyvote.com. D53117-P52171

 

 

Continued and to be signed on reverse side